Saha G K
Department of Medical Entomology, Calcutta School of Tropical Medicine, West Bengal, India.
Ann Allergy. 1993 Apr;70(4):305-9.
A significantly elevated (above 300 U/mL) serum IgE level was found in 97 of 105 dust-sensitive asthmatic patients of Calcutta and the mean value (1002 +/- 614 U/mL) was significantly higher (P << .001) than the control sera. RAST results indicate a higher sensitivity (84.76%) to house dust and house dust mites (Dermatophagoides supp) either alone or in combination with each other. Among positive samples, 79.77%, 71.91%, and 88.76% showed the presence of allergen specific IgE antibodies against house dust (HD), D. pteronyssinus (DP), and D. farinae (DF) mite antigens, respectively. The study highlighted the superiority of D. farinae antigen as a potent allergen in house dust of Calcutta over others and the mites and house dust possibly had a common allergen. The present investigation indicates that RAST sensitivity was independent of age and sex of patients (P > .05). The frequency of RAST sensitivity was observed to be greater in patients suffering for longer durations.
在加尔各答105名对灰尘敏感的哮喘患者中，有97名患者的血清IgE水平显著升高（高于300 U/mL），其平均值（1002±614 U/mL）显著高于对照血清（P<<.001）。放射变应原吸附试验结果表明，单独或相互组合时，对屋尘和屋尘螨（粉尘螨属）的敏感性较高（84.76%）。在阳性样本中，分别有79.77%、71.91%和88.76%显示存在针对屋尘（HD）、粉尘螨（DP）和粗脚粉螨（DF）螨抗原的变应原特异性IgE抗体。该研究强调了粗脚粉螨抗原作为加尔各答屋尘中一种强效变应原优于其他抗原，并且螨和屋尘可能有共同的变应原。目前的调查表明，放射变应原吸附试验的敏感性与患者的年龄和性别无关（P>.05）。观察到病程较长的患者中放射变应原吸附试验敏感性的频率更高。
