Bensi G, Raugei G, Klefenz H, Cortese R
EMBO J. 1985 Jan;4(1):119-26. doi: 10.1002/j.1460-2075.1985.tb02325.x.
Human genomic clones of the haptoglobin Hp1F and the "haptoglobin related' gene (Hpr) have been isolated. The two genes are adjacent, spanning a region of approximately 21 kb. A comparison of their coding sequences shows that Hpr differs from Hp1F at 28 codons. Northern blot and primer elongation analyses with human liver RNA show that the haptoglobin gene Hp1F appears to be transcribed some 1000-fold less in fetal than in adult liver. In adult liver the amount of Hpr mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the Hp1F gene. No Hpr mRNA can be detected in fetal liver.
已分离出触珠蛋白Hp1F和“触珠蛋白相关”基因（Hpr）的人类基因组克隆。这两个基因相邻，跨越约21 kb的区域。对它们编码序列的比较表明，Hpr在28个密码子处与Hp1F不同。用人肝RNA进行的Northern印迹和引物延伸分析表明，触珠蛋白基因Hp1F在胎儿肝脏中的转录量似乎比成人肝脏中少约1000倍。在成人肝脏中，Hpr mRNA的量处于检测下限，因此其表达程度最多不到Hp1F基因的1000倍。在胎儿肝脏中未检测到Hpr mRNA。
