编码α2FSβ和α1Sβ变体的人触珠蛋白cDNA的特征分析。
Characterization of human haptoglobin cDNAs coding for alpha 2FS beta and alpha 1S beta variants.
作者信息
van der Straten A, Herzog A, Cabezón T, Bollen A
出版信息
FEBS Lett. 1984 Mar 12;168(1):103-7. doi: 10.1016/0014-5793(84)80215-x.
PMID:6546723
Abstract
A human liver library, derived from a heterozygous (Hp2-1) donor, has been used to isolate cDNA clones coding for the haptoglobin (Hp) alpha 1S beta and alpha 2FS beta variants. DNA sequencing has shown that the two variants are identical except for the alpha F duplicated segment in Hp alpha 2FS beta. Four nucleotide changes have been found between the phenotypically different F and S regions of the Hp alpha 2 gene, resulting in an Asp,Lys/Asn,Glu substitution.
摘要
一个源自杂合（Hp2-1）供体的人肝脏文库已被用于分离编码触珠蛋白（Hp）α1Sβ和α2FSβ变体的cDNA克隆。DNA测序表明，这两种变体除了Hpα2FSβ中的αF重复片段外是相同的。在Hpα2基因表型不同的F和S区域之间发现了四个核苷酸变化，导致了天冬氨酸、赖氨酸/天冬酰胺、谷氨酸替代。
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