Dilixiati Diliyaer, Kadier Kaisaierjiang, Qiao Bingzhang, Zhang Weijie, Nuerdebieke Daniyaer, Zebibula Abudureheman, Yang Ying, Rexiati Mulati
Department of Urology, Xinjiang Medical University Affiliated First Hospital, Urumqi, Xinjiang, China.
Department of Cardiology, Xinjiang Medical University Affiliated First Hospital, Urumqi, Xinjiang, China.
BMJ Open. 2025 Apr 3;15(4):e084766. doi: 10.1136/bmjopen-2024-084766.
We aimed to investigate the relationship between serum neurofilament light chain (NfL) and grip strength using data from the 2013-2014 US National Health and Nutrition Examination Survey (NHANES).
Secondary analysis of cross-sectional, population-based data.
NHANES sample, 2013-2014.
We studied 1925 participants aged 20-75 years.
We applied a multivariable generalised linear regression model, adjusted for several potential confounders, and restrictive cubic spline models to evaluate the association between serum NfL and grip strength. Subgroup analyses were conducted using stratified multivariable linear regression analysis.
We included 1925 participants (average age: 44.8±0.44 years) from the NHANES database. Participants with higher serum NfL levels had a significantly higher prevalence of medical conditions (hypertension, diabetes, cardiovascular disorder, chronic kidney disease (CKD) and cancer) compared with those with lower NfL levels (all p<0.001). After adjusting for confounding factors, there was a negative association between serum NfL and grip strength (β=-2.07; 95% CI -3.47, -0.67; p=0.007). In addition, significant interactions were found between NfL and grip strength stratified by age, physical activity and CKD (p value for interaction=0.002, 0.023 and 0.006). The results of the restricted cubic splines (RCS) analysis showed no evidence against a linear association of serum NfL levels with grip strength. (p for non-linearity=0.334).
Our study demonstrates a strong, negative and linear correlation between elevated serum NfL levels and grip strength. Notably, our findings indicate that individuals aged between 60 and 75 years, those with physical inactivity and those with CKD exhibit a more pronounced reduction in grip strength with increasing serum NfL levels.
我们旨在利用2013 - 2014年美国国家健康与营养检查调查（NHANES）的数据，研究血清神经丝轻链（NfL）与握力之间的关系。
基于人群的横断面数据的二次分析。
2013 - 2014年NHANES样本。
我们研究了1925名年龄在20 - 75岁之间的参与者。
我们应用多变量广义线性回归模型，并对几个潜在混杂因素进行了调整，同时使用限制性立方样条模型来评估血清NfL与握力之间的关联。采用分层多变量线性回归分析进行亚组分析。
我们纳入了NHANES数据库中的1925名参与者（平均年龄：44.8±0.44岁）。血清NfL水平较高的参与者与NfL水平较低的参与者相比，患有疾病（高血压、糖尿病、心血管疾病、慢性肾脏病（CKD）和癌症）的患病率显著更高（所有p<0.001）。在调整混杂因素后，血清NfL与握力之间存在负相关（β=-2.07；95%CI -3.47，-0.67；p=0.007）。此外，在按年龄、身体活动和CKD分层的NfL与握力之间发现了显著的交互作用（交互作用的p值分别为0.002、0.023和0.006）。限制性立方样条（RCS）分析结果显示，没有证据反对血清NfL水平与握力之间存在线性关联（非线性的p值=0.334）。
我们的研究表明血清NfL水平升高与握力之间存在强烈的负线性相关性。值得注意的是，我们的研究结果表明，年龄在60至75岁之间、身体不活动以及患有CKD的个体，随着血清NfL水平的升高，握力下降更为明显。
