Phillis J W, DeLong R E, Towner J K
Eur J Pharmacol. 1986 May 13;124(1-2):85-91. doi: 10.1016/0014-2999(86)90127-5.
Cerebral blood flow (CBF) in the rat was monitored by a venous outflow technique with an extracorporeal circulation, which allows for the continuous recording of CBF over periods of several hours. Following intraperitoneal administration, two non-steroidal anti-inflammatory agents, indomethacin and ibuprofen (0.01 and 0.1 mg/kg) showed a tendency to increase resting CBF and the reactive hyperemia elicited by a brief (24 s) anoxic challenge was potentiated. A third agent, diclofenac sodium, was less effective, enhancing the hyperemic response only at the higher (0.1 mg/kg) dose level. The results indicate that indomethacin and ibuprofen may be of value in the treatment of diseases involving cerebrovascular insufficiency.
采用体外循环静脉流出技术监测大鼠脑血流量（CBF），该技术可连续数小时记录CBF。腹腔注射两种非甾体抗炎药吲哚美辛和布洛芬（0.01和0.1毫克/千克）后，静息CBF有增加趋势，且短暂（24秒）缺氧刺激引发的反应性充血增强。第三种药物双氯芬酸钠效果较差，仅在较高剂量（0.1毫克/千克）时增强充血反应。结果表明，吲哚美辛和布洛芬在治疗涉及脑血管供血不足的疾病中可能具有价值。
