衰老小鼠运动终板区域雪旺细胞变性的证据。

Evidence of Schwann cell degeneration in the aging mouse motor end-plate region.

作者信息

Ludatscher R M, Silbermann M, Gershon D, Reznick A

出版信息

Exp Gerontol. 1985;20(2):81-91. doi: 10.1016/0531-5565(85)90043-9.

Abstract

An ultrastructural evaluation was made of the changes encountered in the motor endplates of the gastrocnemius muscle of old mice in comparison with young-adult mice. In old, 27-month-old mice, a great variety of changes were recorded. The main abnormalities occurred in the axon terminals, the myoneural junctional folds, and the endomysial space. Loss of synaptic vesicles and mitochondria and vacuolization of axon terminals were common. Shrinkage and degenerative changes of axon terminals were noticed. The end-plate abnormalities were closely associated with an increased amount of collagen tissue, degenerated Schwann cells, and cell debris. Degenerated Schwann cells were not encountered in young-adult mice. In the old group, endplates of normal appearance occurred in the proportion of 40%. The young group had normally structured end-plates in the proportion of 85%. The lesions described are not specific for the aging process.

摘要

对老年小鼠与年轻成年小鼠腓肠肌运动终板所发生的变化进行了超微结构评估。在27月龄的老年小鼠中，记录到了各种各样的变化。主要异常发生在轴突终末、肌神经连接褶和肌内膜间隙。突触小泡和线粒体的丢失以及轴突终末的空泡化很常见。注意到轴突终末有萎缩和退行性变化。终板异常与胶原组织增多、施万细胞变性和细胞碎片密切相关。年轻成年小鼠未出现变性的施万细胞。在老年组中，外观正常的终板占比为40%。年轻组结构正常的终板占比为85%。所描述的病变并非衰老过程所特有。