Hsu S C, Sukhdeo M V, Mettrick D F
Exp Parasitol. 1985 Aug;60(1):55-62. doi: 10.1016/s0014-4894(85)80022-9.
Female CDI mice were inoculated with 10, 50, 100, 250, or 500 larvae of Heligmosomoides polygyrus. At Days 7, 9, and 12 after infection, the anterior third of the small intestine was perfused using an in vivo technique. The distribution of worms in the mouse intestine was determined after 7, 9, and 12 days. All worms that were recovered were from the proximal half of the small intestine. When compared to uninfected controls, there was a significant increase (+56%) in glucose absorption of the small intestine at Day 7 after infection with inocula of 50 and 100 larvae; at Day 9, glucose absorption was significantly increased with a 10-larvae inoculum. A decrease in glucose absorption occurred at Days 7 and 9 after infection with a 500-larvae inoculum. Net water absorption was significantly increased (+183%) with the 50- and 100-larvae inocula at Day 7, but was significantly reduced at Day 9 after infection with the 50-, 100-, 250-, and 500-larvae inocula. Both Cl- and Na+ absorption were significantly increased with the 50-, 100-, and 250-larvae inocula at Day 7 after infection; at 9 and 12 days, there was significant net secretion of both ions. In control mice, there was net secretion of K+, while with the 50-, 100-, and 250-larvae inocula on Day 7 there was significant net absorption of K+ ions.(ABSTRACT TRUNCATED AT 250 WORDS)
将雌性CDI小鼠接种10、50、100、250或500条多枝旋毛虫幼虫。在感染后的第7、9和12天，采用体内技术对小肠前三分之一进行灌注。在第7、9和12天后确定小鼠肠道内蠕虫的分布。所有回收的蠕虫均来自小肠近端的一半。与未感染的对照组相比，感染50和100条幼虫接种物后第7天，小肠葡萄糖吸收显著增加（+56%）；在第9天，接种10条幼虫时葡萄糖吸收显著增加。感染500条幼虫接种物后第7天和第9天，葡萄糖吸收下降。接种50和100条幼虫接种物后第7天，净吸水量显著增加（+183%），但感染50、100、250和500条幼虫接种物后第9天净吸水量显著降低。感染后第7天，接种50、100和250条幼虫接种物时，Cl-和Na+吸收均显著增加；在第9天和第12天，两种离子均有显著的净分泌。在对照小鼠中，有K+的净分泌，而在第7天接种50、100和250条幼虫接种物时，有K+离子的显著净吸收。（摘要截断于250字）
