Braunstein G D, Horton R
Fertil Steril. 1985 Aug;44(2):210-3. doi: 10.1016/s0015-0282(16)48738-8.
Maternal serum concentrations of 3 alpha, 17 beta-androstanediol glucuronide (3 alpha-diol-G), a substance that reflects peripheral androgen action and tissue 5 alpha-reductase activity, were measured in 33 normal men, 51 nonpregnant women, and 51 women with uncomplicated pregnancies. The 3 alpha-diol-G concentrations in men (median, 201 ng/ml) were significantly higher than in nonpregnant women (median, 42 ng/ml) or pregnant women (median, 124 ng/ml). The concentrations in pregnant women were significantly greater than those in nonpregnant women, and there were no significant differences between trimesters in maternal 3 alpha-diol-G concentrations. There were no fetal sex differences found in maternal serum or in third-trimester amniotic fluid. These results indicate that pregnancy is associated with increased androgen production by maternal tissues and that fetal 3 alpha-diol-G production is low.
对33名正常男性、51名未怀孕女性和51名无并发症妊娠女性，检测了反映外周雄激素作用和组织5α-还原酶活性的物质——母体血清中3α,17β-雄甾二醇葡萄糖醛酸苷（3α-二醇-G）的浓度。男性的3α-二醇-G浓度（中位数为201 ng/ml）显著高于未怀孕女性（中位数为42 ng/ml）或怀孕女性（中位数为124 ng/ml）。怀孕女性的浓度显著高于未怀孕女性，且孕期各阶段母体3α-二醇-G浓度无显著差异。在母体血清或孕晚期羊水中未发现胎儿性别差异。这些结果表明，妊娠与母体组织雄激素产生增加有关，且胎儿3α-二醇-G产生量较低。
