Huang Runzhi, Yao Yuntao, Tong Xirui, Wang Lei, Qian Weijin, Lu Jianyu, Zhang Wei, Liu Yifan, Wang Siqiao, Xian Shuyuan, Zhu Yushu, Huang Jie, Guo Xinya, Gu Minyi, Lv Hanlin, Bi Wenshuai, Meng Chenwei, Chang Zhengyan, Zhang Jie, Xu Dayuan, Ji Shizhao
Department of Burn Surgery, First Affiliated Hospital of Naval Medical University, and Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, Shanghai, China.
Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Microbiol Spectr. 2023 Sep 28;11(5):e0013523. doi: 10.1128/spectrum.00135-23.
Gut microbiota can regulate many physiological processes within gastrointestinal tract and other distal sites. Dysbiosis may not only influence chronic diseases like the inflammatory bowel disease (IBD), metabolic disease, tumor and its therapeutic efficacy, but also deteriorate acute injuries. This article aims to review the documents in this field and summarize the research hotspots as well as developing processes. Gut microbiota and immune microenvironment-related documents from 1976 to 2022 were obtained from the Web of Science Core Collection database. Bibliometrics was used to assess the core authors and journals, most contributive countries and affiliations together with hotspots in this field and keyword co-occurrence analysis. Data were visualized to help comprehension. Nine hundred and twelve documents about gut microbiota and immune microenvironment were retrieved, and the annual publications increased gradually. The most productive author, country, and affiliation were "Zitvogel L," USA and "UNIV TEXAS MD ANDERSON CANC CTR," respectively. FRONTIERS IN IMMUNOLOGY, CANCERS, and INTERNATIONAL JOURNAL OF MOLECULAR SCIENCE were the periodicals with most publications. Keyword co-occurrence analysis identified three clusters, including gut microbiota, inflammation, and IBD. Combined with the visualized analysis of documents and keyword co-occurrence as well as literature reading, we recognized three key topics of gut microbiota: cancer and therapy; immunity, inflammation and IBD; acute injuries and metabolic diseases. This article revealed researches on gut microbiota and immune microenvironment were growing. More attention should be given to the latest hotspots like gut microbiota, inflammation, IBD, cancer and immunotherapy, acute traumas, and metabolic diseases.IMPORTANCEGut microbiota can regulate many physiological processes within gastrointestinal tract and other distal sites. Dysbiosis may not only influence chronic diseases like inflammatory bowel disease (IBD), metabolic disease, tumor and its therapeutic efficacy, but also deteriorate acute injuries. While the application of bibliometrics in the field of gut microbiota and immune microenvironment still remains blank, which focused more on the regulation of the gut microbiota on the immune microenvironment of different kinds of diseases. Here, we intended to review and summarize the presented documents in gut microbiota and immune microenvironment field by bibliometrics. And we revealed researches on gut microbiota and immune microenvironment were growing. More attention should be given to the latest hotspots like gut microbiota, inflammation, IBD, cancer and immunotherapy, acute traumas, and metabolic diseases.
肠道微生物群可调节胃肠道及其他远端部位的许多生理过程。微生物群失调不仅可能影响诸如炎症性肠病（IBD）、代谢性疾病、肿瘤及其治疗效果等慢性疾病，还会使急性损伤恶化。本文旨在综述该领域的文献，总结研究热点及发展历程。从Web of Science核心合集数据库获取了1976年至2022年与肠道微生物群和免疫微环境相关的文献。运用文献计量学方法评估核心作者和期刊、贡献最大的国家和机构，以及该领域的热点，并进行关键词共现分析。数据可视化以助理解。共检索到912篇关于肠道微生物群和免疫微环境的文献，年发表量逐渐增加。发文量最多的作者、国家和机构分别是“Zitvogel L”、美国和“德克萨斯大学MD安德森癌症中心”。《免疫学前沿》《癌症》和《国际分子科学杂志》是发文量最多的期刊。关键词共现分析确定了三个聚类，包括肠道微生物群、炎症和IBD。结合文献的可视化分析、关键词共现分析以及文献阅读，我们确定了肠道微生物群的三个关键主题：癌症与治疗；免疫、炎症与IBD；急性损伤与代谢性疾病。本文表明对肠道微生物群和免疫微环境的研究正在增加。应更多关注肠道微生物群、炎症、IBD、癌症与免疫治疗、急性创伤和代谢性疾病等最新热点。
重要性
肠道微生物群可调节胃肠道及其他远端部位的许多生理过程。微生物群失调不仅可能影响诸如炎症性肠病（IBD）、代谢性疾病、肿瘤及其治疗效果等慢性疾病，还会使急性损伤恶化。虽然文献计量学在肠道微生物群和免疫微环境领域的应用仍属空白，但该领域更多关注肠道微生物群对不同疾病免疫微环境的调节。在此，我们旨在通过文献计量学回顾和总结肠道微生物群和免疫微环境领域已发表的文献。我们表明对肠道微生物群和免疫微环境的研究正在增加。应更多关注肠道微生物群、炎症、IBD、癌症与免疫治疗、急性创伤和代谢性疾病等最新热点。
