Cormio Angelo, Mantovan Matteo, Palantrani Vanessa, Beltrami Mattia, Fuligni Demetra, Passarella Valerio, Cammarata Vanessa, Brocca Carlo, Somani Bhaskar K, Gauhar Vineet, Carrieri Giuseppe, Cormio Luigi, Galosi Andrea B, Castellani Daniele
Department of Urology, Azienda Ospedaliero-Universitaria delle Marche, Polytechnic University of Marche, Ancona, Italy -
Department of Urology, Azienda Ospedaliero-Universitaria delle Marche, Polytechnic University of Marche, Ancona, Italy.
Minerva Urol Nephrol. 2025 Feb;77(1):43-51. doi: 10.23736/S2724-6051.25.06001-X.
The aim of this paper was to review the outcomes of shock wave lithotripsy (SWL), ureteroscopy, and percutaneous nephrolithotripsy (PCNL) in kidney stone patients with Congenital Anomalies of the Kidney and Urinary Tract (CAKUT).
A literature search was performed on 15th November 2023 and updated on 18 October 2024 using Cochrane Central Register of Controlled Trials, PubMed, Scopus and Google Scholar with no date limit. Preclinical and animal studies, reviews, letters to editor, case reports, pediatric studies were excluded. Only English papers were included.
Forty-one articles were accepted. Seventeen studies focused on horse-shoe kidney (HSK). Among these, 3 papers focused on RIRS, 9 on PCNL, 5 compared RIRS vs PCNL. The remaining ones explored SWL, RIRS, PCNL in ectopic, malrotated and medullary sponge kidney and caliceal diverticulum stones. HSK, caliceal diverticulum and malrotated kidneys stones treated with SWL have poor stone-free rate, while the best choices are PCNL and ureteroscopy. In ectopic kidneys the best choice is ureteroscopy, SWL has poor stone-free rate, while PCNL is less safe for higher bowel injury risk. In medullary sponge kidneys regardless of the treatment used, stone-free rate is low, with a higher rate of retreatment.
SWL has lower stone-free rate and higher retreatment in all types of CAKUT but has the lowest rate of complications. PCNL has the best stone-free rate in large stone burdens and RIRS is effective procedure although higher reintervention rate and need of pre-stenting in some cases.
本文旨在回顾先天性肾脏和尿路畸形(CAKUT)肾结石患者接受冲击波碎石术(SWL)、输尿管镜检查和经皮肾镜取石术(PCNL)的治疗结果。
于2023年11月15日进行文献检索,并于2024年10月18日更新,使用Cochrane对照试验中央登记册、PubMed、Scopus和谷歌学术搜索,无日期限制。排除临床前和动物研究、综述、致编辑的信、病例报告、儿科研究。仅纳入英文论文。
共纳入41篇文章。17项研究聚焦马蹄肾(HSK)。其中,3篇论文聚焦逆行肾内手术(RIRS),9篇聚焦PCNL,5篇比较RIRS与PCNL。其余研究探讨了SWL、RIRS、PCNL在异位肾、旋转不良肾、髓质海绵肾和肾盂憩室结石中的应用。SWL治疗HSK、肾盂憩室和旋转不良肾结石的无石率较低,而最佳选择是PCNL和输尿管镜检查。对于异位肾,最佳选择是输尿管镜检查,SWL的无石率较低,而PCNL因肠道损伤风险较高而安全性较低。对于髓质海绵肾,无论采用何种治疗方法,无石率都较低,再次治疗率较高。
在所有类型的CAKUT中,SWL的无石率较低且再次治疗率较高,但并发症发生率最低。PCNL在处理大结石负荷时无石率最佳,RIRS是有效的治疗方法,尽管再干预率较高且在某些情况下需要预先置入支架。