Shrestha Dina, Dhingra Atul, Shakya Santosh, Tuladhar Jasmin
Norvic International Hospital, Kathmandu, 44617, Nepal.
Bansal Hospital, Bhopal, India.
Curr Diab Rep. 2025 Apr 4;25(1):28. doi: 10.1007/s11892-025-01582-6.
This review aims to highlight the evolution and multifaceted benefits of modern sulfonylureas (SUs) in managing Type 2 Diabetes Mellitus (T2DM). It discusses their enhanced glycemic control, pleiotropic advantages, usage with other antidiabetic agents, safety, and tolerability, supporting their persistent relevance and effectiveness in diabetes care.
Recent findings indicate that modern SUs, like glimepiride, offer significant cardioprotective and renoprotective benefits along with their primary role in glycemic control. Additionally, they have also shown their anti-inflammatory effects, lipid-lowering properties, testosterone-enhancing effects, and neuroprotective effects in recent years. These findings support the broader therapeutic advantages of modern SUs beyond glucose lowering. Hence, many guidelines now recommend modern SUs as an add-on therapy to metformin. Modern sulfonylureas remain a vital component in T2DM management strategy due to their efficacy, safety profile, and cost-effectiveness. Their pleiotropic benefits, like cardiovascular, renal, anti-inflammatory, neuroprotective effects, etc., make them a comprehensive therapeutic option. Considering their efficacy and safety profile, SUs are expected to remain vital components of antidiabetic therapy, providing valuable benefits in managing T2DM in the long run.
本综述旨在强调现代磺脲类药物（SUs）在治疗2型糖尿病（T2DM）方面的演变及多方面益处。文中讨论了它们在血糖控制方面的强化作用、多效性优势、与其他抗糖尿病药物联合使用的情况、安全性和耐受性，证明了它们在糖尿病治疗中持续的相关性和有效性。
最新研究结果表明，像格列美脲这样的现代磺脲类药物在控制血糖的主要作用之外，还具有显著的心脏保护和肾脏保护作用。此外，近年来它们还展现出抗炎、降脂、提高睾酮水平以及神经保护作用。这些发现支持了现代磺脲类药物在降糖之外更广泛的治疗优势。因此，现在许多指南推荐将现代磺脲类药物作为二甲双胍的联合治疗药物。现代磺脲类药物因其疗效、安全性和成本效益，仍然是T2DM管理策略中的重要组成部分。它们的多效性益处，如心血管、肾脏、抗炎、神经保护作用等，使其成为一种全面的治疗选择。考虑到其疗效和安全性，磺脲类药物有望长期作为抗糖尿病治疗的重要组成部分，在管理T2DM方面提供有价值的益处。
