Guo Lingyu, An Tian
Department of Urology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Dermatology and Plastic Surgery, The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang, China.
Medicine (Baltimore). 2025 Jan 3;104(1):e41141. doi: 10.1097/MD.0000000000041141.
Previous studies in observational epidemiology have suggested a potential correlation between the gastrointestinal tract microbiota and prostate cancer. However, the causal relationship between the 2 remains uncertain, our objective was to thoroughly examine the influence of the gut microbiome on the progression of prostate cancer. In this study, we focused on investigating the gut microbiome as an exposure factor, specifically analyzing data from the MiBioGen consortium, which had a substantial sample size of 18,340 participants. As our disease outcome, we utilized prostate cancer data from the FinnGen genome-wide association study, which involved 13,216 participants. To establish causal relationships, we conducted a comprehensive Mendelian randomization analysis employing multiple methods, including inverse variance-weighted, Mendelian randomization-Egger, maximum likelihood, and weighted median approaches. Additionally, we performed sensitivity analysis to address issues such as heterogeneity and horizontal pleiotropy, ensuring the robustness of our findings. The results obtained through inverse variance-weighted analysis revealed that certain microbial groups exhibited a protective effect on prostate cancer. Specifically, the phylum Verrucomicrobia, particularly the family Rikenellaceae, and the genera Anaerotruncus, Eisenbergiella, Olsenella, and Parabacteroides were found to have a beneficial impact. Conversely, the class Bacilli, class Erysipelotrichia, order Erysipelotrichales, order Lactobacillales, family Erysipelotrichaceae, and the genera Marvinbryantia, Romboutsia, Ruminococcaceae UCG002, and Sutterella had an adverse influence on prostate cancer. The sensitivity analysis did not reveal any such outliers, further strengthening the validity of our results. To summarize, a cause-and-effect connection was discovered between various types and prostate cancer. Nevertheless, additional randomized controlled experiments are required for validation.
既往观察性流行病学研究表明，胃肠道微生物群与前列腺癌之间可能存在关联。然而，两者之间的因果关系仍不明确，我们的目标是全面研究肠道微生物群对前列腺癌进展的影响。在本研究中，我们重点调查肠道微生物群作为一个暴露因素，具体分析了来自MiBioGen联盟的数据，该联盟样本量很大，有18340名参与者。作为我们的疾病结局，我们使用了来自芬兰基因组全关联研究的前列腺癌数据，该研究涉及13216名参与者。为了建立因果关系，我们采用多种方法进行了全面的孟德尔随机化分析，包括逆方差加权法、孟德尔随机化-伊格法、最大似然法和加权中位数法。此外，我们进行了敏感性分析，以解决异质性和水平多效性等问题，确保我们研究结果的稳健性。通过逆方差加权分析得到的结果显示，某些微生物群对前列腺癌具有保护作用。具体而言，疣微菌门，尤其是理研菌科，以及厌氧短杆菌属、艾氏菌属、奥尔森菌属和拟杆菌属被发现具有有益影响。相反，芽孢杆菌纲、丹毒丝菌纲、丹毒丝菌目、乳杆菌目、丹毒丝菌科，以及马文氏菌属、罗姆布茨菌属、瘤胃球菌科UCG002和萨特菌属对前列腺癌有不利影响。敏感性分析未发现任何此类异常值，进一步加强了我们结果的有效性。总之，发现了不同类型与前列腺癌之间的因果联系。然而，还需要额外的随机对照实验来进行验证。
