Davis M D, Hubbard L D, Trautman J, Klein R
Diabetes. 1985 Aug;34 Suppl 3:42-9. doi: 10.2337/diab.34.3.s42.
A major goal of the study was to assess the methodologies available for the quantification of retinal lesions suitable for application in trials of metabolic management. We describe the methods used for grading stereoscopic color fundus photographs. Overall retinopathy severity level for each eye ranging from normal (level 10) to high-risk category (level 70) was assigned on the basis of gradings of individual lesions. Change in retinopathy severity level over the 8-mo period was detected in 3-62% of patients, depending on the method used and the definition of change. Lesions responsible for change in level were mainly retinal infarcts (soft exudates) and intraretinal microvascular abnormalities.
该研究的一个主要目标是评估可用于量化视网膜病变的方法，这些方法适用于代谢管理试验。我们描述了用于对立体彩色眼底照片进行分级的方法。根据个体病变的分级，为每只眼睛确定了从正常（10级）到高危类别（70级）的总体视网膜病变严重程度级别。在8个月期间，3%至62%的患者检测到视网膜病变严重程度级别发生了变化，具体取决于所使用的方法和变化的定义。导致级别变化的病变主要是视网膜梗死（软性渗出）和视网膜内微血管异常。
