The IGF Signalling Axis in Lung Cancer: Clinical Significance and Therapeutic Challenges.
作者信息
Papavassiliou Kostas A, Sofianidi Amalia A, Cholidou Kyriaki, Papavassiliou Athanasios G
机构信息
First University Department of Respiratory Medicine, 'Sotiria' Chest Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
出版信息
J Cell Mol Med. 2025 Apr;29(7):e70540. doi: 10.1111/jcmm.70540.
Abstract
摘要
相似文献
1
The IGF Signalling Axis in Lung Cancer: Clinical Significance and Therapeutic Challenges.肺癌中的胰岛素样生长因子信号轴：临床意义与治疗挑战
J Cell Mol Med. 2025 Apr;29(7):e70540. doi: 10.1111/jcmm.70540.
2
Different Roles of the Insulin-like Growth Factor (IGF) Axis in Non-small Cell Lung Cancer.胰岛素样生长因子（IGF）轴在非小细胞肺癌中的不同作用。
Curr Pharm Des. 2022;28(25):2052-2064. doi: 10.2174/1381612828666220608122934.
3
Drugging IGF-1R in cancer: New insights and emerging opportunities.癌症中靶向胰岛素样生长因子-1受体（IGF-1R）：新见解与新机遇
Genes Dis. 2022 Mar 23;10(1):199-211. doi: 10.1016/j.gendis.2022.03.002. eCollection 2023 Jan.
4
Growth Hormone/Insulin Growth Factor Axis in Sex Steroid Associated Disorders and Related Cancers.生长激素/胰岛素样生长因子轴在性类固醇相关疾病及相关癌症中的作用
Front Cell Dev Biol. 2021 Mar 18;9:630503. doi: 10.3389/fcell.2021.630503. eCollection 2021.
5
Genetic variations in the IGF-IGFR-IGFBP axis confer susceptibility to lung and esophageal cancer.胰岛素样生长因子（IGF）-胰岛素样生长因子受体（IGFR）-胰岛素样生长因子结合蛋白（IGFBP）轴的基因变异会使人易患肺癌和食管癌。
Genet Mol Res. 2014 Jan 24;13(1):2107-19. doi: 10.4238/2014.January.24.17.
6
IGF signalling in germ cells and testicular germ cell tumours: roles and therapeutic approaches.IGF 信号在生殖细胞和睾丸生殖细胞肿瘤中的作用及治疗方法。
Andrology. 2019 Jul;7(4):536-544. doi: 10.1111/andr.12658. Epub 2019 Jun 9.
7
Activation of the IGF Axis in Thyroid Cancer: Implications for Tumorigenesis and Treatment.甲状腺癌中 IGF 轴的激活：对肿瘤发生和治疗的影响。
Int J Mol Sci. 2019 Jul 2;20(13):3258. doi: 10.3390/ijms20133258.
8
Recent update on IGF-1/IGF-1R signaling axis as a promising therapeutic target for triple-negative breast cancer.IGF-1/IGF-1R 信号轴作为三阴性乳腺癌有前途的治疗靶点的最新研究进展。
Pathol Res Pract. 2024 Nov;263:155620. doi: 10.1016/j.prp.2024.155620. Epub 2024 Sep 26.
9
The rationale and development of therapeutic insulin-like growth factor axis inhibition for lung and other cancers.治疗性胰岛素样生长因子轴抑制在肺癌和其他癌症中的作用机制和发展。
Clin Lung Cancer. 2009 Jul;10(4):262-72. doi: 10.3816/CLC.2009.n.037.
10
Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts.胰岛素样生长因子I受体阻断增强了化疗和放疗反应，并抑制人胃癌异种移植瘤的生长。
Gut. 2005 May;54(5):591-600. doi: 10.1136/gut.2004.048926.
本文引用的文献
1
circ_PPAPDC1A promotes Osimertinib resistance by sponging the miR-30a-3p/ IGF1R pathway in non-small cell lung cancer (NSCLC).circ_PPAPDC1A 通过海绵吸附 miR-30a-3p/IGF1R 通路促进非小细胞肺癌（NSCLC）对奥希替尼的耐药性。
Mol Cancer. 2024 May 7;23(1):91. doi: 10.1186/s12943-024-01998-w.
2
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.2022 年全球癌症统计数据：全球 185 个国家和地区 36 种癌症的发病率和死亡率全球估计数。
CA Cancer J Clin. 2024 May-Jun;74(3):229-263. doi: 10.3322/caac.21834. Epub 2024 Apr 4.
3
The tobacco-specific carcinogen NNK induces pulmonary tumorigenesis via nAChR/Src/STAT3-mediated activation of the renin-angiotensin system and IGF-1R signaling.烟草特异性致癌原 NNK 通过烟碱型乙酰胆碱受体/原癌基因Src/信号转导与转录激活因子 3 介导的肾素-血管紧张素系统和胰岛素样生长因子 1 受体信号通路诱导肺肿瘤发生。
Exp Mol Med. 2023 Jun;55(6):1131-1144. doi: 10.1038/s12276-023-00994-2. Epub 2023 Jun 1.
4
Dasatinib in combination with BMS-754807 induce synergistic cytotoxicity in lung cancer cells through inhibiting lung cancer cell growth, and inducing autophagy as well as cell cycle arrest at the G1 phase.达沙替尼联合 BMS-754807 通过抑制肺癌细胞生长、诱导自噬和细胞周期阻滞在 G1 期，在肺癌细胞中诱导协同细胞毒性。
Invest New Drugs. 2023 Jun;41(3):438-452. doi: 10.1007/s10637-023-01360-9. Epub 2023 Apr 25.
5
Different Roles of the Insulin-like Growth Factor (IGF) Axis in Non-small Cell Lung Cancer.胰岛素样生长因子（IGF）轴在非小细胞肺癌中的不同作用。
Curr Pharm Des. 2022;28(25):2052-2064. doi: 10.2174/1381612828666220608122934.
6
IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells.肿瘤相关成纤维细胞分泌的 IGF 结合蛋白诱导肺癌细胞的上下文相关药物敏感性。
Sci Signal. 2022 Aug 16;15(747):eabj5879. doi: 10.1126/scisignal.abj5879.
7
IGF1R acts as a cancer-promoting factor in the tumor microenvironment facilitating lung metastasis implantation and progression.IGF1R 在肿瘤微环境中充当促进癌症的因素，促进肺转移种植和进展。
Oncogene. 2022 Jul;41(28):3625-3639. doi: 10.1038/s41388-022-02376-w. Epub 2022 Jun 10.
8
Editorial: The Role of the IGF/Insulin-IGFBP Axis in Normal Physiology and Disease.社论：胰岛素样生长因子/胰岛素-胰岛素样生长因子结合蛋白轴在正常生理和疾病中的作用
Front Endocrinol (Lausanne). 2022 Apr 21;13:892140. doi: 10.3389/fendo.2022.892140. eCollection 2022.
9
The role of IGF-pathway biomarkers in determining risks, screening, and prognosis in lung cancer.IGF 通路生物标志物在肺癌风险评估、筛查和预后中的作用。
Oncotarget. 2022 Feb 18;13:393-407. doi: 10.18632/oncotarget.28202. eCollection 2022.
10
Short-term starvation reduces IGF-1 levels to sensitize lung tumors to PD-1 immune checkpoint blockade.短期饥饿可降低胰岛素样生长因子-1（IGF-1）水平，使肺肿瘤对程序性死亡受体-1（PD-1）免疫检查点阻断敏感。
Nat Cancer. 2020 Jan;1(1):75-85. doi: 10.1038/s43018-019-0007-9. Epub 2020 Jan 13.
Zotero 插件