Cao Man, Chen Yan, Shen Xudong
Department of Nutrition, Wuhu City Second Peoplès Hospital Wuhu, Hefei, Anhui, China.
Department of Emergency Medicine, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, Anhui, 230001, China.
Urolithiasis. 2025 Apr 5;53(1):67. doi: 10.1007/s00240-025-01741-0.
The study aimed to explore the association between the ZJU (Zhejiang University) index and the prevalence of kidney stones in Chinese adults. Electronic health records of individuals undergoing routine physical examinations at Wuhu Second People's Hospital between January 2021 and June 2024 were retrospectively analyzed. Participants were divided into kidney stone recurrence and non-recurrence groups. Data on biochemical parameters, hypertension, and diabetes history were collected, and group differences were assessed using the chi-square test or Kruskal-Wallis rank-sum test. Logistic regression, propensity score matching, and dose-response curve modeling were used to evaluate the relationship between the ZJU index and kidney stone prevalence. Among 5,104 participants aged over 18 years, 462 were diagnosed with kidney stones. After adjusting for confounders, a higher ZJU index was identified as an independent risk factor for kidney stone prevalence (odds ratio [OR] = 1.05, 95% confidence interval [CI]: 1.02-1.08). Propensity score-matched analysis further confirmed this association (OR = 1.09, 95% CI: 1.04-1.13). Dose-response analysis revealed a positive linear relationship between the ZJU index and kidney stone recurrence. These findings suggest that elevated ZJU index levels are associated with a higher prevalence and recurrence of kidney stones, highlighting its potential as a clinical tool for identifying and managing at-risk patients.
该研究旨在探讨浙江大学（ZJU）指数与中国成年人肾结石患病率之间的关联。对2021年1月至2024年6月期间在芜湖市第二人民医院接受常规体检的个体的电子健康记录进行回顾性分析。参与者被分为肾结石复发组和非复发组。收集生化参数、高血压和糖尿病史的数据，并使用卡方检验或Kruskal-Wallis秩和检验评估组间差异。采用逻辑回归、倾向得分匹配和剂量反应曲线建模来评估ZJU指数与肾结石患病率之间的关系。在5104名18岁以上的参与者中，462人被诊断为肾结石。在调整混杂因素后，较高的ZJU指数被确定为肾结石患病率的独立危险因素（比值比[OR]=1.05，95%置信区间[CI]：1.02-1.08）。倾向得分匹配分析进一步证实了这种关联（OR=1.09，95%CI：1.04-1.13）。剂量反应分析显示ZJU指数与肾结石复发之间存在正线性关系。这些发现表明，ZJU指数水平升高与肾结石的较高患病率和复发率相关，凸显了其作为识别和管理高危患者的临床工具的潜力。
