Ikehara S, Shimamura K, Aoyama T, Fujii S, Hamashima Y
Immunology. 1985 Aug;55(4):595-600.
FUT-175 (6-amidino-2-naphthyl p-guanidinobenzoate dimethanesulphonate), a new synthetic protease inhibitor, was administrated to (NZB x NZB) F1 mice in order to examine its influence on the development of autoimmune diseases. A dose (400 mg/kg of body weight) of FUT-175 has both prophylactic and curative effects on the development of lupus nephritis: mice showed a significantly low percentage of proteinuria, a marked decrease in BUN levels, and the lowest degree of glomerular damages. Dexamethasone had almost the same effect as FUT-175 (400 mg/kg), but it was slightly less effective than FUT-175. These results suggest that the administration of FUT-175 may become a viable strategy for the treatment of human autoimmune diseases.
FUT - 175（6 - 脒基 - 2 - 萘基对 - 胍基苯甲酸盐二甲磺酸盐），一种新型合成蛋白酶抑制剂，被给予（新西兰黑鼠×新西兰黑鼠）F1代小鼠，以研究其对自身免疫性疾病发展的影响。FUT - 175剂量为400毫克/千克体重时，对狼疮性肾炎的发展具有预防和治疗作用：小鼠蛋白尿百分比显著降低，血尿素氮水平明显下降，肾小球损伤程度最低。地塞米松与FUT - 175（400毫克/千克）效果几乎相同，但稍逊于FUT - 175。这些结果表明，给予FUT - 175可能成为治疗人类自身免疫性疾病的可行策略。
