Caignard A, Martin M S, Michel M F, Martin F
Int J Cancer. 1985 Aug 15;36(2):273-9. doi: 10.1002/ijc.2910360221.
From a single, chemically-induced rat colonic carcinoma, two subpopulations of tumor cells have been isolated. When injected into syngeneic rats, TR cells give rise to progressive tumors in most of the animals, whereas TS cells give rise to no tumors or to tumors which regress in less than 30 days. TS cells inhibit the growth of TR tumors, whether they are injected before TR cells or simultaneously, at a different site or mixed with the TR cells. Lymph nodes and spleen lymphocytes from animals having rejected TS tumors also inhibit TR-cell growth. On the other hand, TS cells are able to give rise to progressive tumors when they are injected into rats bearing established TR tumors. Lymph nodes and spleen cells of TR tumor-bearing rats are able to enhance TS cell growth. These results suggest that subpopulations of cancer cells contained in the same tumor interact with each other through their effect on the host immune system. The growth of a whole tumor probably depends not only on the growth potential of each constituent subpopulation, but also on the interaction between the subpopulations themselves.
从单一化学诱导的大鼠结肠癌中，分离出了两个肿瘤细胞亚群。当注射到同基因大鼠体内时，TR细胞在大多数动物中会引发进行性肿瘤，而TS细胞不会引发肿瘤，或者引发在不到30天内消退的肿瘤。TS细胞会抑制TR肿瘤的生长，无论它们是在TR细胞之前注射、同时注射、在不同部位注射还是与TR细胞混合注射。来自已排斥TS肿瘤的动物的淋巴结和脾淋巴细胞也会抑制TR细胞的生长。另一方面，当TS细胞注射到已建立TR肿瘤的大鼠体内时，它们能够引发进行性肿瘤。携带TR肿瘤的大鼠的淋巴结和脾细胞能够促进TS细胞的生长。这些结果表明，同一肿瘤中所含的癌细胞亚群通过它们对宿主免疫系统的影响而相互作用。整个肿瘤的生长可能不仅取决于每个组成亚群的生长潜力，还取决于亚群之间的相互作用。
