Pawlowski Z S
Int J Clin Pharmacol Res. 1985;5(2):75-8.
Cystic (E. granulosus) echinococcosis is an important medical problem in Mediterranean countries where the dog-sheep-dog strain predominates. This mainly man-made infection is susceptible to control programmes directed against the infections in dogs. In man, surgery still remains a major curative intervention. Some benzimidazole compounds (mebendazole, albendazole) are effective in some cases of cystic echinococcosis, however, further studies on more effective drugs are recommended. At present chemotherapy should be used only in inoperable cases of cystic echinococcosis in man. Alveolar (E. multilocularis) echinococcosis is diagnosed more and more frequently in some regions of Central Europe. Man cannot interfere much with the reservoir of E. multilocularis in wild life, but should be able to protect himself and his dogs against infection from natural foci. High doses of mebendazole taken continuously have shown to increase substantially the survival rate of infected patients. However, further studies are needed to improve the efficacy of chemotherapy and to make it available to all those patients who have not been cured by surgery.
囊性（细粒棘球绦虫）棘球蚴病是地中海国家的一个重要医学问题，在这些国家，犬-羊-犬传播链占主导地位。这种主要由人为因素导致的感染易于通过针对犬类感染的防控计划加以控制。对人类而言，手术仍然是主要的治疗手段。一些苯并咪唑类化合物（甲苯达唑、阿苯达唑）在某些囊性棘球蚴病病例中有效，然而，建议对更有效的药物开展进一步研究。目前，化疗仅应用于人类无法进行手术的囊性棘球蚴病病例。在中欧的一些地区，泡状（多房棘球绦虫）棘球蚴病的诊断越来越频繁。人类对野生动物体内多房棘球绦虫的宿主难以施加太多干预，但应能够保护自己及其犬类免受自然疫源地感染。持续服用高剂量甲苯达唑已显示可大幅提高感染患者的生存率。然而，需要进一步研究以提高化疗效果，并使其能够应用于所有未通过手术治愈的患者。
