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Genetic mutations across multiple pathways drive filamentous growth and virulence in the emerging fungal pathogen Candida auris.

作者信息

Li Chao, Li Shuaihu, Zheng Qiushi, Tao Li, Bing Jian, Guan Zhangyue, Hu Tianren, Chu Haiqing, Huang Guanghua

机构信息

Shanghai Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetic Engineering, School of Life Sciences, Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, 200438, China.

Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, China.

出版信息

Sci China Life Sci. 2025 Apr 3. doi: 10.1007/s11427-024-2902-9.

DOI:10.1007/s11427-024-2902-9
PMID:40189489
Abstract
摘要

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本文引用的文献

1
Infections.感染
N Engl J Med. 2024 Nov 21;391(20):1924-1935. doi: 10.1056/NEJMra2402635.
2
Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection.在系统性感染过程中,新型隐球菌的适应性多细胞形态迅速进化。
Nat Commun. 2024 Mar 16;15(1):2381. doi: 10.1038/s41467-024-46786-8.
3
Morphogenic plasticity: the pathogenic attribute of Candida albicans.形态发生可塑性:白色念珠菌的致病属性。
Curr Genet. 2023 Jun;69(2-3):77-89. doi: 10.1007/s00294-023-01263-5. Epub 2023 Mar 22.
4
Candida auris: Epidemiology, biology, antifungal resistance, and virulence.耳念珠菌:流行病学、生物学、抗真菌耐药性和毒力。
PLoS Pathog. 2020 Oct 22;16(10):e1008921. doi: 10.1371/journal.ppat.1008921. eCollection 2020 Oct.
5
Hemizygosity Enables a Mutational Transition Governing Fungal Virulence and Commensalism.杂合性使控制真菌毒力和共生关系的突变转变成为可能。
Cell Host Microbe. 2019 Mar 13;25(3):418-431.e6. doi: 10.1016/j.chom.2019.01.005. Epub 2019 Feb 26.
6
Genetic and phenotypic intra-species variation in Candida albicans.白色念珠菌的种内遗传和表型变异。
Genome Res. 2015 Mar;25(3):413-25. doi: 10.1101/gr.174623.114. Epub 2014 Dec 11.
7
Environmental sensing and signal transduction pathways regulating morphopathogenic determinants of Candida albicans.调节白色念珠菌形态致病决定因素的环境感知与信号转导途径。
Microbiol Mol Biol Rev. 2007 Jun;71(2):348-76. doi: 10.1128/MMBR.00009-06.