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In the era of 100-year life spans, will esaxerenone be positioned as a second-line treatment for any age group?

作者信息

Yoshida Tetsuro

机构信息

Department of Cardiovascular Medicine, Onga Nakama Medical Association Onga Hospital, Onga, Fukuoka, Japan.

出版信息

Hypertens Res. 2025 Apr;48(4):1624-1626. doi: 10.1038/s41440-025-02133-y. Epub 2025 Mar 28.

DOI:10.1038/s41440-025-02133-y
PMID:40189654
Abstract
摘要

相似文献

1
In the era of 100-year life spans, will esaxerenone be positioned as a second-line treatment for any age group?在人均寿命达百岁的时代，依沙克瑞诺会被定位为针对任何年龄组的二线治疗药物吗？
Hypertens Res. 2025 Apr;48(4):1624-1626. doi: 10.1038/s41440-025-02133-y. Epub 2025 Mar 28.
2
Rationale and design of a multicenter randomized study comparing the efficacy and safety of esaxerenone versus trichlormethiazide in patients with uncontrolled essential hypertension: EXCITE-HT study.一项多中心随机研究比较依普利酮与三氯甲噻嗪在未控制的原发性高血压患者中的疗效和安全性的原理和设计：EXCITE-HT 研究。
J Clin Hypertens (Greenwich). 2023 Sep;25(9):861-867. doi: 10.1111/jch.14705. Epub 2023 Aug 7.
3
Home blood pressure-lowering effect of a non-steroidal mineralocorticoid receptor blocker, esaxerenone, versus trichlormethiazide for uncontrolled hypertension: the EXCITE-HT randomized controlled study.依普利酮降低血压疗效优于三氯噻嗪用于治疗未控制的高血压：EXCITE-HT 随机对照研究
Hypertens Res. 2024 Sep;47(9):2435-2446. doi: 10.1038/s41440-024-01762-z. Epub 2024 Jul 23.
4
Home blood pressure-lowering effect of esaxerenone versus trichlormethiazide for uncontrolled hypertension: a predefined subanalysis of the EXCITE-HT randomized controlled trial by basal calcium channel blocker versus angiotensin receptor blocker.依普利酮与三氯噻嗪对血压控制不佳的高血压患者的家庭血压降低效果：EXCITE-HT随机对照试验按基础钙通道阻滞剂与血管紧张素受体阻滞剂进行的预定义亚组分析
Hypertens Res. 2025 Feb;48(2):506-518. doi: 10.1038/s41440-024-01887-1. Epub 2024 Oct 12.
5
Home blood pressure-lowering effect of esaxerenone vs trichlormethiazide for uncontrolled hypertension: a prespecified subanalysis of the EXCITE-HT randomized controlled study by age subgroup.依普利酮与三氯噻嗪对血压控制不佳的高血压患者的家庭血压降低效果：EXCITE-HT随机对照研究按年龄亚组进行的预先指定亚分析
Hypertens Res. 2025 Apr;48(4):1586-1598. doi: 10.1038/s41440-024-02078-8. Epub 2025 Mar 28.
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Effects of the novel nonsteroidal mineralocorticoid receptor blocker, esaxerenone (CS-3150), on blood pressure and urinary angiotensinogen in low-renin Dahl salt-sensitive hypertensive rats.新型非甾体盐皮质激素受体阻滞剂依斯巴伦诺（CS-3150）对低肾素型 Dahl 盐敏感型高血压大鼠血压和尿血管紧张素原的影响。
Hypertens Res. 2019 Jun;42(6):769-778. doi: 10.1038/s41440-018-0187-1. Epub 2018 Dec 26.
7
Effects of esaxerenone on blood pressure, urinary albumin excretion, serum levels of NT-proBNP, and quality of life in patients with primary aldosteronism.依普利酮对原发性醛固酮增多症患者血压、尿白蛋白排泄、血清 NT-proBNP 水平和生活质量的影响。
Hypertens Res. 2024 Jan;47(1):157-167. doi: 10.1038/s41440-023-01412-w. Epub 2023 Sep 17.
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Upregulation of Piezo2 in the mesangial, renin, and perivascular mesenchymal cells of the kidney of Dahl salt-sensitive hypertensive rats and its reversal by esaxerenone.Dahl 盐敏感性高血压大鼠肾脏系膜细胞、肾素和血管周围间质细胞中 Piezo2 的上调及其被 esaxerenone 逆转。
Hypertens Res. 2023 May;46(5):1234-1246. doi: 10.1038/s41440-023-01219-9. Epub 2023 Feb 21.
9
Will esaxerenone be added to the antihypertensive treatment strategy of practicing physicians as a second-line antihypertensive drug?依沙克瑞诺会作为二线降压药物被添加到执业医师的降压治疗策略中吗？
Hypertens Res. 2024 Sep;47(9):2574-2576. doi: 10.1038/s41440-024-01802-8. Epub 2024 Jul 11.
10
Rationale and Design of a Randomized, Open-Label, Parallel-Group Study of Esaxerenone Versus Angiotensin Receptor Blockers in Older Patients With Uncontrolled Hypertension on Calcium Channel Blocker Monotherapy (ESCORT-HT).依普利酮与血管紧张素受体阻滞剂治疗钙通道阻滞剂单药治疗血压控制不佳的老年患者的随机、开放标签、平行组研究（ESCORT-HT）的原理与设计
J Clin Hypertens (Greenwich). 2025 Jan;27(1):e14947. doi: 10.1111/jch.14947. Epub 2024 Nov 25.

本文引用的文献

1
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019).日本高血压学会高血压管理指南（JSH 2019）。
Hypertens Res. 2019 Sep;42(9):1235-1481. doi: 10.1038/s41440-019-0284-9.
2
Polypharmacy as a risk for fall occurrence in geriatric outpatients.老年门诊患者中，多重用药与跌倒发生的风险。
Geriatr Gerontol Int. 2012 Jul;12(3):425-30. doi: 10.1111/j.1447-0594.2011.00783.x. Epub 2011 Dec 23.