Levi Richard, Birberg Thornberg Ulrika, Blystad Ida, Divanoglou Anestis, Engblom David, Leon Felipe, Morberg Jämterud Sofia, Zeiler Kristin
Department of Rehabilitation Medicine and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Department of Radiology Linköping, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden; Centre for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.
J Rehabil Med. 2025 Apr 6;57:jrm42254. doi: 10.2340/jrm.v57.42254.
To present a radically interdisciplinary research approach to ill-defined symptoms, with a focus on fatigue as a major symptom of post COVID-19 condition, where multiple and, to date, rarely combined approaches may yield a fuller understanding of these symptoms.
Protocol for a mixed-methods study comprising an interdisciplinary cross-analysis.
35 persons with post COVID-19 condition and severe fatigue were included, and 35 age-, sex-, and educationally matched controls who recovered from COVID-19 without post COVID-19 condition.
Participants were assessed by a multidisciplinary research team as follows: physician assessment; blood and urinalysis; spirometry and physical performance tests; neuropsychological tests; structural and functional magnetic resonance imaging; extended immunological tests (cytokines); and qualitative phenomenological analysis of interviews. Data will be analysed in accordance with established methods in each of these research fields and by a cross-analysis methodology developed from within an enactive framework. This framework encompasses a focus on neuroscientific, physiological, and experiential aspects of the person as a living being in their sociocultural world.
The biopsychosocial model needs to be implemented in research according to methods that allow radically different research paradigms, typically seen as incommensurable, to inform each other in a non-reductionist manner. One application of such an approach is therefore described.
提出一种针对不明确症状的全新跨学科研究方法，重点关注疲劳作为新冠后状况的主要症状，在这种情况下，多种（且迄今为止很少结合使用）方法可能会使我们对这些症状有更全面的理解。
一项包括跨学科交叉分析的混合方法研究方案。
纳入35例患有新冠后状况且严重疲劳的患者，以及35例年龄、性别和教育程度匹配的对照者，这些对照者从新冠中康复且无新冠后状况。
由一个多学科研究团队对参与者进行如下评估：医生评估；血液和尿液分析；肺活量测定和体能测试；神经心理学测试；结构和功能磁共振成像；扩展免疫测试（细胞因子）；以及访谈的定性现象学分析。数据将根据这些研究领域中既定的方法以及从具身认知框架内开发的交叉分析方法进行分析。该框架涵盖了对作为社会文化世界中生命体的人的神经科学、生理学和体验方面的关注。
生物心理社会模型需要在研究中按照允许根本不同（通常被视为不可通约）的研究范式以非还原论的方式相互提供信息的方法来实施。因此描述了这种方法的一种应用。
