Seelbach J D, Etherton T D, Kris-Etherton P M
Int J Obes. 1985;9(1):11-9.
Four-week-old male lean and obese Zucker rats were subjected to intense daily exercise for a 10-week period. The exercise regimen used (running 6 days/week for 90 min/day on a treadmill at 1.3 Km/h at an 8 per cent grade) was designed to maximize the amount of exercise performed. Lean and obese runners (LR and OR) gained significantly less weight than sedentary controls (LS and OS). Food intake was lower in LR and unchanged in OR compared with control animals. Exercise increased adrenal weight in runners of both phenotypes. Gastrocnemius muscle weight was significantly higher in OR compared to OS. Despite the intense exercise regimen, carcass fat of OR was reduced only 12 per cent versus OS. In contrast, exercise decreased carcass fat by 32 per cent in LR versus LS. This decrease in body fat of LR was due to smaller adipocytes. Exercise did not affect adipocyte size in obese rats. However, OR had fewer carcass adipocytes. These results indicate that exercise had substantially different effects on adipose tissue cellularity of lean and obese rats. The results of the present study indicate that a program of intense treadmill exercise initiated immediately post weaning only modestly reduced adipose tissue growth in obese Zucker rats. Furthermore, it did not normalize body composition.
对4周龄的雄性瘦型和肥胖型Zucker大鼠进行为期10周的每日高强度运动。所采用的运动方案（每周6天，每天在坡度为8%的跑步机上以1.3公里/小时的速度跑步90分钟）旨在使运动量最大化。与久坐不动的对照组（LS和OS）相比，瘦型和肥胖型跑步大鼠（LR和OR）体重增加明显较少。与对照动物相比，LR的食物摄入量较低，而OR的食物摄入量没有变化。运动增加了两种表型跑步大鼠的肾上腺重量。与OS相比，OR的腓肠肌重量明显更高。尽管运动方案强度很大，但与OS相比，OR的胴体脂肪仅减少了12%。相比之下，与LS相比，运动使LR的胴体脂肪减少了32%。LR体脂的减少是由于脂肪细胞较小。运动对肥胖大鼠的脂肪细胞大小没有影响。然而，OR的胴体脂肪细胞较少。这些结果表明，运动对瘦型和肥胖型大鼠的脂肪组织细胞构成有显著不同的影响。本研究结果表明，断奶后立即开始的高强度跑步机运动方案仅适度减少了肥胖型Zucker大鼠的脂肪组织生长。此外，它并没有使身体成分正常化。
