Huang Lan, Liao Jing, Lu Chunyan, Yin Yiqiong, Ma Yanling, Wen Yue
Division of Gastrointestinal Surgery, Department of General Surgery, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, China.
Front Endocrinol (Lausanne). 2025 Mar 21;16:1407873. doi: 10.3389/fendo.2025.1407873. eCollection 2025.
The visceral adiposity index is a valuable tool for assessing visceral fat accumulation. However, its non-linear association with prediabetes and diabetes requires further elucidation. Therefore, we aim to clarify the intricate interplay between the visceral adiposity index and these dysglycemic conditions.
The National Health and Nutrition Examination Survey database from 1999 to 2018 was utilized to analyze health data from 24,072 participants. A multivariate logistic regression model was employed to evaluate the independent association between the visceral adiposity index and prediabetes and diabetes while considering potential confounding factors. Generalized additive models were used to identify any non-linear relationships by fitting smooth curves. Additionally, a stratified analysis based on different baseline characteristics was conducted, along with an interactive analysis.
After accounting for all relevant variables, individuals in the lowest quartile of the visceral adiposity index had a notably diminished likelihood of progressing to prediabetes and diabetes when compared with those in the other three quartiles. The odds ratios and 95% confidence intervals were as follows: 1.37 (1.23, 1.53), 1.87 (1.65, 2.12), and 2.80 (2.33, 3.37). More importantly, a non-linear association was observed between the visceral adiposity index and prediabetes and diabetes, with a threshold identified at 2.10.
There exists a notable and positive association between the visceral adiposity index and prediabetes and diabetes, displaying non-linear attributes in this evaluation of the relationship. Risk assessment and early prevention strategies targeting the maintenance of low levels of visceral adiposity index may substantially diminish the likelihood of developing prediabetes and diabetes.
内脏脂肪指数是评估内脏脂肪堆积的一个有价值的工具。然而，其与糖尿病前期和糖尿病之间的非线性关联需要进一步阐明。因此，我们旨在阐明内脏脂肪指数与这些血糖异常状况之间的复杂相互作用。
利用1999年至2018年的美国国家健康与营养检查调查数据库来分析24072名参与者的健康数据。采用多因素逻辑回归模型来评估内脏脂肪指数与糖尿病前期和糖尿病之间的独立关联，同时考虑潜在的混杂因素。使用广义相加模型通过拟合平滑曲线来识别任何非线性关系。此外，还进行了基于不同基线特征的分层分析以及交互分析。
在考虑了所有相关变量后，与其他三个四分位数的个体相比，内脏脂肪指数处于最低四分位数的个体进展为糖尿病前期和糖尿病的可能性显著降低。优势比和95%置信区间如下：1.37（1.23，1.53）、1.87（1.65，2.12）和2.80（2.33，3.37）。更重要的是，观察到内脏脂肪指数与糖尿病前期和糖尿病之间存在非线性关联，确定的阈值为2.10。
内脏脂肪指数与糖尿病前期和糖尿病之间存在显著的正相关，在这种关系评估中呈现出非线性特征。针对维持低水平内脏脂肪指数的风险评估和早期预防策略可能会大幅降低患糖尿病前期和糖尿病的可能性。
