中国2型糖尿病成年患者中脂质蓄积产物与代谢功能障碍相关脂肪性肝病的相关性

Correlation Between Lipid Accumulation Product and Metabolic Dysfunction-Associated Steatotic Liver Disease in Chinese Adults with Type 2 Diabetes Mellitus.

作者信息

Liu Wei, Xu Lingling, Yu Yuan, Qiao Liang, Zhang Lijuan, Chu Xiaoqiu, Jing Haibo, Cao Lin

机构信息

Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210028, People's Republic of China.

Department of Gastroenterology, Jiangning Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu, 211100, People's Republic of China.

出版信息

Diabetes Metab Syndr Obes. 2025 Jun 24;18:2007-2017. doi: 10.2147/DMSO.S518649. eCollection 2025.

DOI:10.2147/DMSO.S518649

PMID:40583876

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12205747/

Abstract

OBJECTIVE

To evaluate the value and feasibility of the lipid accumulation product (LAP) in the prediction of metabolic dysfunction-associated steatotic liver disease (MASLD) in Chinese adults with type 2 diabetes mellitus (T2DM).

METHODS

In this cross-sectional study, we assessed the value of LAP and other novel indices in the prediction of MASLD in Chinese adults with T2DM in a total of 642 patients. Receiver Operating Characteristic (ROC) curves were plotted to assess the predictive ability of the indices for the occurrence of MASLD in T2DM.

RESULTS

The results showed that LAP had a strong predictive ability for the occurrence of MASLD in T2DM in both men and women and was superior to other traditional visceral fat-related indices. In men, the area under curve (AUC) (95% CI) was 0.815 (0.771-0.859) with cut-off value of 36.01, and its sensitivity and specificity were 71.91% and 77.44%, respectively. And in women, the AUC (95% CI) was 0.816 (0.762-0.870) with cut-off value of 24.22, and its sensitivity and specificity were 84.93% and 63.54%, respectively.

CONCLUSION

LAP has a high predictive ability for the occurrence of MASLD in T2DM in both men and women and are superior to other traditional visceral fat-related indices.

摘要

目的

评估脂质蓄积产物（LAP）对中国2型糖尿病（T2DM）成年患者代谢功能障碍相关脂肪性肝病（MASLD）的预测价值及可行性。

方法

在这项横断面研究中，我们评估了LAP及其他新指标对642例中国T2DM成年患者MASLD的预测价值。绘制受试者工作特征（ROC）曲线，以评估这些指标对T2DM患者发生MASLD的预测能力。

结果

结果显示，LAP对T2DM患者发生MASLD具有较强的预测能力，且优于其他传统的内脏脂肪相关指标。在男性中，曲线下面积（AUC）（95%CI）为0.815（0.771-0.859），截断值为36.01，其敏感性和特异性分别为71.91%和77.44%。在女性中，AUC（95%CI）为0.816（0.762-0.870），截断值为24.22，其敏感性和特异性分别为84.93%和63.54%。