作为与甲萘醌加合物给药的硫胺素的生物利用度。
Bioavailability of the thiamin administered as an adduct with menadione.
作者信息
Laffi R, Tossani N, Marchi-Marchetti M
出版信息
Int J Vitam Nutr Res. 1985;55(2):181-5.
In order to investigate the bioavailability of thiamin present in the adduct with menadione bisulfite, urinary and faecalis excretion, blood levels and tissue content of thiamin in rats after oral administration of this compound, were measured. Since the quantity of thiamin excreted, the blood levels as well as the vitamin storage in the liver and kidney of rats treated with the adduct are similar to those of rats treated with corresponding quantities of thiamin HCl and menadione sodium bisulfite this means that the thiamin contained in the adduct reacts in the same way as free vitamin in the animal organism.
为了研究与亚硫酸氢甲萘醌加合物中硫胺素的生物利用度，测定了大鼠口服该化合物后硫胺素的尿排泄和粪排泄、血液水平及组织含量。由于用该加合物处理的大鼠排泄的硫胺素量、血液水平以及肝脏和肾脏中的维生素储存量与用相应量的盐酸硫胺素和亚硫酸氢甲萘醌钠处理的大鼠相似，这意味着加合物中所含的硫胺素在动物体内的反应方式与游离维生素相同。
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