Arkhipova O P
Vopr Med Khim. 1975 Sep-Oct;21(5):485-9.
Effects of tuberculous infection and monotherapy during three months with ethyone amide, etoxide and canamycin on thiamin metabolism were studied. The state of the metabolism was estimated by monitoring the content of radioactive thiamin in tissues and blood and by following its excretion. In guinea pigs generalized tuberculosis caused impairments in utilization of the administered thiamin. Content of the vitamin was decreased 3.5-4 fold in tissues, especially, in kidney and liver tissue but its excretion from the organism was increased almost three-fold as compared with healthy animals. Treatment of animals with ethyone amide, etoxide and canamycin within three months did not restore the impaired thiamin metabolism. In the animals the assimilation of the administered thiamin constituted 17,5-20% as compared with healthy animals; this phenomenon was accompanied by an increased urinary excretion of the vitamin.
研究了结核感染以及使用乙硫异烟胺、乙氧苯硫脲和卡那霉素进行三个月单一疗法对硫胺素代谢的影响。通过监测组织和血液中放射性硫胺素的含量及其排泄情况来评估代谢状态。在豚鼠中，全身性结核病导致所给予硫胺素的利用出现障碍。与健康动物相比，该维生素在组织中的含量，尤其是在肾脏和肝脏组织中降低了3.5至4倍，但其从机体的排泄量增加了近三倍。用乙硫异烟胺、乙氧苯硫脲和卡那霉素对动物进行三个月的治疗并未恢复受损的硫胺素代谢。与健康动物相比，这些动物对所给予硫胺素的同化率为17.5%至20%；这种现象伴随着该维生素尿排泄量的增加。
