Pontoriero Antonio, Critelli Paola, Zeppieri Marco, Bosurgi Alberto, Guercio Stefania, Caffo Maria, Angileri Filippo Flavio, Parisi Silvana, Lavalle Salvatore, Pergolizzi Stefano
Radiation Oncology Unit, Department of Biomedical, Dental Science and Morphological and Functional Images, University of Messina, Messina 98125, Italy.
Department of Ophthalmology, University Hospital of Udine, Udine 33100, Italy.
World J Clin Cases. 2025 Apr 6;13(10):101719. doi: 10.12998/wjcc.v13.i10.101719.
Precision medicine is an emerging field that includes tumor-targeted delivery and tumor microenvironment. This review explores the synergistic potential of combining nano-drug delivery systems with low radiation doses to achieve optimized therapeutic outcomes, particularly in the context of cancer treatment. Nanoparticle-based drug carriers offer precise and targeted delivery, enhancing the therapeutic index of anticancer agents. The use of lower radiation doses has become a focus in radiation oncology to minimize off-target effects on healthy tissues in palliation treatment with high-target volume lesions.
To conduct a bibliometric review of nanomedicine and glioblastoma (GBM), all relevant studies from the last two decades were included.
The search strategy comprised the keywords "nanomedicine "and "glioblastoma" in the title and/or abstract. All English-language documents from 1 January 2000 to 31 December 2023 were considered for the analysis. R code (version 4.2.0) with R Studio (version 2022.12.0-353) and the Bibliometrix package (version 4.0.1) were used for the analysis. A total of 680 documents were collected.
We analyzed the bibliometric features of nanomedicine in glioma. With the limitations of the research, our analysis aims to highlight the increasing interest of researchers in the precision medicine field in GBM treatment and lead us to suggest further studies focusing on the association between nanomedicine and radiotherapy.
Due to the poor prognosis associated with GBM, new therapeutic approaches are necessary. There is an increasing interest in precision medicine, which includes nanomedicine and radiotherapy, for GBM treatment This integration enhances the efficacy of targeted treatments and provides a promising avenue for reducing adverse effects, signifying a notable advancement in precision oncology.
精准医学是一个新兴领域，包括肿瘤靶向递送和肿瘤微环境。本综述探讨了将纳米药物递送系统与低辐射剂量相结合以实现优化治疗效果的协同潜力，特别是在癌症治疗背景下。基于纳米颗粒的药物载体可实现精确靶向递送，提高抗癌药物的治疗指数。在高靶体积病变的姑息治疗中，使用较低辐射剂量已成为放射肿瘤学的一个重点，以尽量减少对健康组织的脱靶效应。
对纳米医学与胶质母细胞瘤（GBM）进行文献计量学综述，纳入过去二十年的所有相关研究。
检索策略包括在标题和/或摘要中使用关键词“纳米医学”和“胶质母细胞瘤”。分析考虑了2000年1月1日至2023年12月31日期间的所有英文文献。使用带有R Studio（版本2022.12.0 - 353）的R代码（版本4.2.0）和Bibliometrix软件包（版本4.0.1）进行分析。共收集到680篇文献。
我们分析了纳米医学在胶质瘤中的文献计量学特征。鉴于研究的局限性，我们的分析旨在突出精准医学领域研究人员对GBM治疗的兴趣日益增加，并促使我们建议进一步开展聚焦于纳米医学与放射治疗之间关联的研究。
由于GBM的预后较差，需要新的治疗方法。对于GBM治疗，包括纳米医学和放射治疗在内的精准医学越来越受到关注。这种整合提高了靶向治疗的疗效，并为减少不良反应提供了一条有前景的途径，标志着精准肿瘤学取得了显著进展。
