Yu Kaitao, Yin Baobing, Zhu Ying, Meng Hongdao, Zhu Wenwei, Lu Lu, Wang Junqiao, Chen Shugeng, Ni Jun, Lin Yifang, Jia Jie
Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China, 86 136 1172 2357.
Department of General Surgery, Hepatobiliary Surgery, Huashan Hospital, Fudan University, Shanghai, China.
JMIR Mhealth Uhealth. 2025 Apr 7;13:e59228. doi: 10.2196/59228.
Rehabilitation is considered a fundamental component of cancer treatment, especially for patients undergoing cancer surgery. In contrast to conventional rehabilitation education, digital rehabilitation has the potential to improve patients' access to postoperative rehabilitation programs. While digital health has rapidly emerged to aid patients with various diseases, their clinical efficacy in the recovery of patients with primary liver cancer (PLC) undergoing hepatectomy remains inadequately investigated.
This study aims to evaluate whether a digital postoperative rehabilitation intervention is efficient in improving physical fitness, enhancing exercise adherence, and alleviating fatigue among patients with PLC after hepatectomy.
A randomized controlled trial was undertaken across 2 university-affiliated hospitals in Eastern China. A total of 100 participants were enrolled in this study and were allocated randomly to either the digital health (intervention group, n=50) or the rehabilitation manual-based group (control group, n=50) at a 1:1 ratio. Patients were unblinded and prospectively followed for the intervention of 3 weeks. Outcome measures included physical fitness, exercise adherence, and status of fatigue.
Overall, 91 out of 100 patients completed the research and were evaluated after 3 weeks of intervention. The digital health group showed better cardiopulmonary endurance than the control group. The mean difference in the change of 6-minute walk test distance from baseline between the groups was 70.21 (95% CI 0.730-82.869) m (P=.05). No statistically significant effects were found for grip strength, 5-repetition-sit-to-stand test time, and fatigue. The exercise adherence in the digital health group was higher than that in the control group (χ22=15.871, P<.001).
The findings suggested that the implementation of digital health had a positive impact on recovery in exercise capacity after hepatectomy. In addition, rehabilitation exercise mode based on digital health has the potential to improve the exercise adherence of patients with PLC compared to conventional manual-based rehabilitation guidance.
康复被认为是癌症治疗的基本组成部分，尤其是对于接受癌症手术的患者。与传统的康复教育相比，数字康复有潜力改善患者术后康复计划的可及性。虽然数字健康已迅速兴起以帮助患有各种疾病的患者，但其对接受肝切除术的原发性肝癌（PLC）患者康复的临床疗效仍未得到充分研究。
本研究旨在评估数字术后康复干预是否能有效改善肝切除术后PLC患者的身体素质、增强运动依从性并减轻疲劳。
在中国东部的2家大学附属医院进行了一项随机对照试验。本研究共纳入100名参与者，以1:1的比例随机分配到数字健康组（干预组，n = 50）或基于康复手册的组（对照组，n = 50）。患者不设盲，并前瞻性随访3周的干预情况。结局指标包括身体素质、运动依从性和疲劳状态。
总体而言，100名患者中有91名完成了研究，并在干预3周后进行了评估。数字健康组的心肺耐力优于对照组。两组之间6分钟步行试验距离相对于基线变化的平均差异为70.21（95%CI 0.730 - 82.869）m（P = 0.05）。握力、5次坐立试验时间和疲劳方面未发现统计学上的显著影响。数字健康组的运动依从性高于对照组（χ22 = 15.871，P < 0.001）。
研究结果表明，数字健康的实施对肝切除术后运动能力的恢复有积极影响。此外，与传统的基于手册的康复指导相比，基于数字健康的康复运动模式有潜力提高PLC患者的运动依从性。
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