Wickramanayake P D, Loeffler M, Klein H O, Groth W, Wichmann H E
J Cancer Res Clin Oncol. 1985;110(1):11-6. doi: 10.1007/BF00402496.
A human malignant melanoma was grown in nude mice. The tumour showed an exponential growth for several weeks which gradually slowed down, until following week 8 the tumour growth ceased. The reasons for this growth pattern were examined by labelling techniques (PLM, LI). The tumour cell production as quantified by the growth fraction, showed only a moderate reduction which, taken alone, could not explain the growth cessation. The important mechanism seems to be an increased loss of tumour cells during the intermitotic interval. While the loss of cells/h remains constant the total intermitotic cell loss is increased because the cell cycle times are prolonged by 50% from the exponential phase (45 h in week 3) to the plateau phase (66 h in week 8).
将人类恶性黑色素瘤接种于裸鼠体内。肿瘤在数周内呈指数生长，随后逐渐减缓，直至第8周后肿瘤生长停止。通过标记技术（PLM、LI）研究了这种生长模式的原因。通过生长分数量化的肿瘤细胞产生仅出现适度降低，仅据此无法解释生长停止现象。重要的机制似乎是在分裂间期肿瘤细胞损失增加。虽然每小时的细胞损失保持恒定，但总的分裂间期细胞损失增加，因为细胞周期时间从指数生长期（第3周为45小时）到平台期（第8周为66小时）延长了50%。
