Fu Xinyu, Liu Chunyu, Gong Pihua, Gao Zhancheng
Department of Pulmonary and Critical Care Medicine, Peking University People's Hospital, Beijing, CHN.
Cureus. 2025 Mar 7;17(3):e80195. doi: 10.7759/cureus.80195. eCollection 2025 Mar.
Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by exposure to environmental antigens in susceptible individuals. It is a type IV hypersensitivity reaction. The antigens involved in HP are numerous, but their identification is challenging. We report the first clinical case of HP associated with exposure to paprika. The diagnosis was confirmed based on the patient's exposure history, chest imaging, bronchoalveolar lavage fluid analysis, and pathological findings. Avoidance of antigens and treatment with glucocorticoids resulted in symptom relief. Follow-up chest imaging showed no ideal improvement; immunosuppressants or antifibrotic drugs may be considered in combination if necessary. The case highlights that individuals working in paprika production and processing should take preventive measures to avoid chronic pulmonary fibrosis.
过敏性肺炎（HP）是一种间质性肺病，由易感个体暴露于环境抗原引起。它是一种IV型超敏反应。与HP相关的抗原众多，但对其进行鉴定具有挑战性。我们报告了首例与接触辣椒粉相关的HP临床病例。根据患者的接触史、胸部影像学、支气管肺泡灌洗分析及病理结果确诊。避免接触抗原并使用糖皮质激素治疗可缓解症状。随访胸部影像学检查显示改善不理想；必要时可考虑联合使用免疫抑制剂或抗纤维化药物。该病例强调，从事辣椒粉生产和加工的人员应采取预防措施以避免慢性肺纤维化。
