Le Hanh Tran Nguyen, Tran Tam Vo Viet, Le Minh Tran Khoi, Phan Anh Le Thu, Nguyen Khoi Tan
School of Biotechnology, International University, Vietnam National University of Ho Chi Minh City 700000 Vietnam
RSC Adv. 2025 Apr 7;15(14):10873-10883. doi: 10.1039/d5ra00334b. eCollection 2025 Apr 4.
Ultrafine bubbles with ultrasound stimuli have recently gained immense attention in developing drug delivery systems. However, research into their construction, stability and the factors influencing this aspect was conducted at the infant stage. This study aimed to utilize silk fibroin (a biocompatible protein extracted from silkworm) in conjugation with polyethylene glycol 400 to stabilize the ultrafine bubble drug loading and releasing system. Light scattering laser imaging was used to examine the effects of SF and PEG on system stability. In addition, fluorescence laser imaging and optical absorbance measurements were performed to assess the role of these additives in the drug encapsulation and release process. Results confirmed the bubble stability was enhanced by the introduction of SF and PEG into the drug-carrier system. This study demonstrated that the proposed drug-transportation system possessed an encapsulation capacity of more than 80% and a substantial released drug content of up to 50% after the application of ultrasonic radiation.
近年来，具有超声刺激的超细气泡在药物递送系统的开发中备受关注。然而，关于其构建、稳定性以及影响这方面的因素的研究尚处于起步阶段。本研究旨在利用丝素蛋白（一种从蚕中提取的生物相容性蛋白质）与聚乙二醇400结合，以稳定超细气泡载药和释药系统。采用光散射激光成像技术研究丝素蛋白（SF）和聚乙二醇（PEG）对系统稳定性的影响。此外，还进行了荧光激光成像和光吸收测量，以评估这些添加剂在药物包封和释放过程中的作用。结果证实，将SF和PEG引入药物载体系统可增强气泡稳定性。本研究表明，所提出的药物输送系统在施加超声辐射后具有超过80%的包封能力和高达50%的大量药物释放量。
