Deng Gaoju, Cao Yuan, Qiu Changjian
Mental Health Center, West China Hospital of Sichuan University, Sichuan Clinical Medical Research Center for Mental Disorders, No. 37 Guo Xue Alley, Chengdu, Sichuan, China.
People's Hospital of Fengjie, Chongqing, China.
BMC Psychiatry. 2025 Apr 7;25(1):341. doi: 10.1186/s12888-025-06774-8.
The functional and structural abnormalities of cortico-striato-thalamo-cortex have been reported to be associated with the neurobiological basis of obsessive-compulsive disorder (OCD). OCD can also occur in the striatum damaging after brain infarction, which is called OCD caused by physical diseases. The relationship and mechanism between temporal lobe abnormalities and OCD are still unclear.
A young male with temporal lobe porencephaly presented with obsessive-compulsive symptoms. The cognition of this OCD participant was not significantly impaired, and his social function was well maintained. After treatment with sertraline, aripiprazole, and fluvoxamine, he was improved but relapsed several times after drug withdrawal. However, the therapeutic effect was sustained upon reinitiation of the medication.
This is the first reported case of OCD in an individual with left temporal lobe porencephaly. The possible relationship between obsessive-compulsive symptoms and temporal lobe structural abnormalities needs to be further studied. The maintenance treatment and prognosis of organic obsessive-compulsive disorder also deserve further study.
据报道，皮质-纹状体-丘脑-皮质的功能和结构异常与强迫症（OCD）的神经生物学基础有关。OCD也可发生在脑梗死导致纹状体受损后，称为由躯体疾病引起的OCD。颞叶异常与OCD之间的关系及机制仍不清楚。
一名患有颞叶孔洞脑的年轻男性出现强迫症状。该OCD患者的认知功能未受到明显损害，其社会功能保持良好。经舍曲林、阿立哌唑和氟伏沙明治疗后病情好转，但停药后多次复发。然而，重新用药后治疗效果得以维持。
这是首例报道的左侧颞叶孔洞脑患者患OCD的病例。强迫症状与颞叶结构异常之间的可能关系有待进一步研究。器质性强迫症的维持治疗和预后也值得进一步研究。
