• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

儿童强迫症症状激发的神经相关因素。

Neural correlates of symptom provocation in pediatric obsessive-compulsive disorder.

机构信息

Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, Canada; British Columbia Children's Hospital Research Institute, Vancouver, Canada.

British Columbia Children's Hospital Research Institute, Vancouver, Canada.

出版信息

Neuroimage Clin. 2019;24:102034. doi: 10.1016/j.nicl.2019.102034. Epub 2019 Oct 23.

DOI:10.1016/j.nicl.2019.102034
PMID:31734533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6861668/
Abstract

OBSESSIVE-COMPULSIVE DISORDER: (OCD)-affected adults and children exhibit three to four symptom dimensions with distinct but overlapping neural correlates. No symptom provocation behavioural or imaging study has examined all symptom dimensions in a pediatric OCD sample. METHOD: Clinically diagnosed pediatric OCD-affected participants (n = 25) as well as age, gender and Tanner pubertal stage-matched healthy controls (HCs; n = 24) (total sample: mean age = 14.77 ± 2.93 years; age range = 9-18 years; 35% male) viewed alternating blocks of OCD symptom provocation (Contamination, Bad Thoughts, and Just Right symptom dimensions), Fear, Neutral and Rest (i.e. fixation) conditions during functional magnetic resonance imaging. A region-of-interest analysis used seeds based upon results of an adult OCD meta-analysis RESULTS: OCD participants found OCD symptom-related stimuli bothersome, particularly when compared to controls in the "Just Right" symptom dimension. Pediatric OCD patients exhibited greater recruitment of the left superior temporal gyrus (STG) than healthy controls during combined symptom provocation versus neutral conditions. CONCLUSION: Findings suggest involvement of the temporal poles rather than in classic cortico-striatal-thalamico-cortical circuits in pediatric OCD during symptom provocation.

摘要

强迫症

（OCD）受影响的成年人和儿童表现出三个到四个症状维度，具有不同但重叠的神经相关性。没有任何症状诱发的行为或成像研究在儿科 OCD 样本中检查了所有症状维度。方法：对临床诊断为 OCD 受影响的参与者（n=25）以及年龄、性别和 Tanner 青春期阶段匹配的健康对照者（HCs；n=24）（总样本：平均年龄=14.77±2.93 岁；年龄范围=9-18 岁；35%为男性）进行了功能磁共振成像，观察交替的 OCD 症状诱发（污染、不良想法和恰到好处症状维度）、恐惧、中性和固定（即固定）条件。基于成人 OCD 荟萃分析的结果，使用基于种子的感兴趣区域分析。结果：与对照组相比，OCD 参与者发现与 OCD 症状相关的刺激令人烦恼，尤其是在“恰到好处”症状维度。与中性条件相比，儿科 OCD 患者在联合症状诱发时表现出左侧颞上回（STG）的更大募集。结论：研究结果表明，在儿科 OCD 中，在症状诱发期间，颞极而不是经典的皮质-纹状体-丘脑-皮质回路参与其中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dce/6861668/ab2741e1b97b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dce/6861668/e0d6b5fb563d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dce/6861668/d46d86d1d83a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dce/6861668/ab2741e1b97b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dce/6861668/e0d6b5fb563d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dce/6861668/d46d86d1d83a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dce/6861668/ab2741e1b97b/gr3.jpg

相似文献

1
Neural correlates of symptom provocation in pediatric obsessive-compulsive disorder.儿童强迫症症状激发的神经相关因素。
Neuroimage Clin. 2019;24:102034. doi: 10.1016/j.nicl.2019.102034. Epub 2019 Oct 23.
2
Neural correlates of symptom dimensions in pediatric obsessive-compulsive disorder: a functional magnetic resonance imaging study.儿童强迫症症状维度的神经关联：一项功能磁共振成像研究。
J Am Acad Child Adolesc Psychiatry. 2009 Sep;48(9):936-944. doi: 10.1097/CHI.0b013e3181b2163c.
3
Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder.强迫症中洗涤、检查和囤积症状维度的不同神经关联。
Arch Gen Psychiatry. 2004 Jun;61(6):564-76. doi: 10.1001/archpsyc.61.6.564.
4
An fMRI study of cognitive planning before and after symptom provocation in pediatric obsessive-compulsive disorder.一项关于儿童强迫症症状前和症状后认知计划的 fMRI 研究。
J Psychiatry Neurosci. 2022 Nov 22;47(6):E409-E420. doi: 10.1503/jpn.220064. Print 2022 Nov-Dec.
5
Symptom provocation in obsessive-compulsive disorder: A voxel-based meta-analysis and meta-analytic connectivity modeling.强迫症中的症状激发：基于体素的元分析和元分析连接性建模。
J Psychiatr Res. 2022 Feb;146:125-134. doi: 10.1016/j.jpsychires.2021.12.029. Epub 2021 Dec 23.
6
Associations of cortical thickness, surface area and subcortical volumes with insight in drug-naïve adults with obsessive-compulsive disorder.皮质厚度、表面积和皮质下体积与药物初治强迫症成年患者领悟力的相关性。
Neuroimage Clin. 2019;24:102037. doi: 10.1016/j.nicl.2019.102037. Epub 2019 Oct 16.
7
Relationship between symptom dimensions and brain morphology in obsessive-compulsive disorder.强迫症症状维度与大脑形态的关系。
Brain Imaging Behav. 2017 Oct;11(5):1326-1333. doi: 10.1007/s11682-016-9611-9.
8
Spontaneous neural activity in the right superior temporal gyrus and left middle temporal gyrus is associated with insight level in obsessive-compulsive disorder.右侧颞上回和左侧颞中回的自发神经活动与强迫症的洞察力水平相关。
J Affect Disord. 2017 Jan 1;207:203-211. doi: 10.1016/j.jad.2016.08.027. Epub 2016 Oct 2.
9
Intrinsic brain abnormalities in drug-naive patients with obsessive-compulsive disorder: A resting-state functional MRI study.药物初治强迫症患者的内在大脑异常：一项静息态功能磁共振成像研究。
J Affect Disord. 2019 Feb 15;245:861-868. doi: 10.1016/j.jad.2018.11.080. Epub 2018 Nov 13.
10
White matter structural alterations in pediatric obsessive-compulsive disorder: relation to symptom dimensions.儿童强迫症的白质结构改变：与症状维度的关系
Prog Neuropsychopharmacol Biol Psychiatry. 2014 Oct 3;54:249-58. doi: 10.1016/j.pnpbp.2014.06.009. Epub 2014 Jun 28.

引用本文的文献

1
Obsessive-compulsive disorder and temporal lobe porencephaly: a case report.强迫症与颞叶孔洞脑畸形：一例报告
BMC Psychiatry. 2025 Apr 7;25(1):341. doi: 10.1186/s12888-025-06774-8.
2
An fMRI study of cognitive planning before and after symptom provocation in pediatric obsessive-compulsive disorder.一项关于儿童强迫症症状前和症状后认知计划的 fMRI 研究。
J Psychiatry Neurosci. 2022 Nov 22;47(6):E409-E420. doi: 10.1503/jpn.220064. Print 2022 Nov-Dec.
3
Temporal Stability of Dynamic Default Mode Network Connectivity Negatively Correlates with Suicidality in Major Depressive Disorder.

本文引用的文献

1
Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium.强迫症中皮质和皮质下不对称性的映射：来自ENIGMA联盟的研究结果。
Biol Psychiatry. 2020 Jun 15;87(12):1022-1034. doi: 10.1016/j.biopsych.2019.04.022. Epub 2019 Apr 30.
2
Modeling Group-Level Repeated Measurements of Neuroimaging Data Using the Univariate General Linear Model.使用单变量一般线性模型对神经影像数据进行组水平重复测量建模。
Front Neurosci. 2019 Apr 17;13:352. doi: 10.3389/fnins.2019.00352. eCollection 2019.
3
Handling Multiplicity in Neuroimaging Through Bayesian Lenses with Multilevel Modeling.
重度抑郁症中动态默认模式网络连接性的时间稳定性与自杀倾向呈负相关。
Brain Sci. 2022 Sep 17;12(9):1263. doi: 10.3390/brainsci12091263.
4
Comparison of resting-state spontaneous brain activity between treatment-naive schizophrenia and obsessive-compulsive disorder.治疗初发精神分裂症与强迫症患者静息态自发脑活动的比较。
BMC Psychiatry. 2021 Nov 3;21(1):544. doi: 10.1186/s12888-021-03554-y.
5
Developmental Considerations in Obsessive Compulsive Disorder: Comparing Pediatric and Adult-Onset Cases.强迫症的发育考量：儿童期起病与成人期起病病例的比较
Front Psychiatry. 2021 Jun 14;12:678538. doi: 10.3389/fpsyt.2021.678538. eCollection 2021.
6
Decreased left amygdala functional connectivity by cognitive-coping therapy in obsessive-compulsive disorder.认知行为疗法降低强迫症患者左侧杏仁核功能连接。
Mol Psychiatry. 2021 Nov;26(11):6952-6962. doi: 10.1038/s41380-021-01131-z. Epub 2021 May 7.
7
An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration.ENIGMA 强迫症工作组成立 5 年概述：全球合作的力量。
Hum Brain Mapp. 2022 Jan;43(1):23-36. doi: 10.1002/hbm.24972. Epub 2020 Mar 10.
通过多层建模的贝叶斯镜头处理神经影像学中的多重性。
Neuroinformatics. 2019 Oct;17(4):515-545. doi: 10.1007/s12021-018-9409-6.
4
Obsessive-compulsive symptom dimensions: Association with comorbidity profiles and cognitive-behavioral therapy outcome in pediatric obsessive-compulsive disorder.强迫症状维度：与儿科强迫症共病谱及认知行为治疗结果的关系。
Psychiatry Res. 2018 Dec;270:317-323. doi: 10.1016/j.psychres.2018.09.054. Epub 2018 Sep 22.
5
Developing image sets for inducing obsessive-compulsive checking symptoms.开发诱发强迫症检查症状的图像集。
Psychiatry Res. 2018 Jul;265:249-255. doi: 10.1016/j.psychres.2018.04.035. Epub 2018 Apr 22.
6
Emotional Processing in Obsessive-Compulsive Disorder: A Systematic Review and Meta-analysis of 25 Functional Neuroimaging Studies.强迫症中的情绪处理：25 项功能神经影像学研究的系统回顾和荟萃分析。
Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Jun;3(6):563-571. doi: 10.1016/j.bpsc.2018.01.009. Epub 2018 Feb 3.
7
Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group.与儿童和成人强迫症相关的皮质异常：来自 ENIGMA 强迫症工作组的研究结果。
Am J Psychiatry. 2018 May 1;175(5):453-462. doi: 10.1176/appi.ajp.2017.17050485. Epub 2017 Dec 15.
8
OCD: obsessive-compulsive … disgust? The role of disgust in obsessive-compulsive disorder.强迫症：强迫性……厌恶？厌恶在强迫症中的作用。
J Psychiatry Neurosci. 2017 Sep;42(5):300-306. doi: 10.1503/jpn.160079.
9
Obsessions and compulsions in the lab: A meta-analysis of procedures to induce symptoms of obsessive-compulsive disorder.实验室中的强迫观念和强迫行为：诱发强迫症症状的程序的荟萃分析。
Clin Psychol Rev. 2017 Mar;52:137-147. doi: 10.1016/j.cpr.2017.01.001. Epub 2017 Jan 16.
10
Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis.儿童和成人强迫症患者不同的皮质下体积改变：一项全球荟萃分析和大型分析
Am J Psychiatry. 2017 Jan 1;174(1):60-69. doi: 10.1176/appi.ajp.2016.16020201. Epub 2016 Sep 9.