Huang Chao, Englitz Bernhard, Reznik Andrey, Zeldenrust Fleur, Celikel Tansu
Department of Neurophysiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, the Netherlands.
Laboratory of Neural Circuits and Plasticity, University of Southern California, 3616 Watt Way, Los Angeles, CA 90089, United States.
Cereb Cortex. 2025 Apr 1;35(4). doi: 10.1093/cercor/bhaf073.
Transformation of postsynaptic potentials into action potentials is the rate-limiting step of communication in neural networks. The efficiency of this intracellular information transfer also powerfully shapes stimulus representations in sensory cortices. Using whole-cell recordings and information-theoretic measures, we show herein that somatic postsynaptic potentials accurately represent stimulus location on a trial-by-trial basis in single neurons, even 4 synapses away from the sensory periphery in the whisker system. This information is largely lost during action potential generation but can be rapidly (<20 ms) recovered using complementary information in local populations in a cell-type-specific manner. These results show that as sensory information is transferred from one neural locus to another, the circuits reconstruct the stimulus with high fidelity so that sensory representations of single neurons faithfully represent the stimulus in the periphery, but only in their postsynaptic potentials, resulting in lossless information processing for the sense of touch in the primary somatosensory cortex.
突触后电位向动作电位的转变是神经网络中信息传递的限速步骤。这种细胞内信息传递的效率也有力地塑造了感觉皮层中的刺激表征。通过全细胞记录和信息论方法，我们在此表明，在单个神经元中，体细胞突触后电位在逐个试次的基础上准确地代表刺激位置，即使在胡须系统中距离感觉外周4个突触远的地方也是如此。这些信息在动作电位产生过程中大部分丢失，但可以使用局部群体中的互补信息以细胞类型特异性方式快速（<20毫秒）恢复。这些结果表明，随着感觉信息从一个神经位点传递到另一个神经位点，神经回路以高保真度重建刺激，使得单个神经元的感觉表征忠实地代表外周的刺激，但仅在其突触后电位中如此，从而导致初级体感皮层中触觉的无损信息处理。
