Klockars M, Weber T, Tanner P, Hellström P E, Pettersson T
J Clin Pathol. 1985 Jul;38(7):818-24. doi: 10.1136/jcp.38.7.818.
The concentration of ferritin was measured in the pleural fluid of 108 patients with pleural effusions. In all groups of patients the ferritin concentration was higher in pleural fluid than in serum. The greatest differences, with up to 100 times more ferritin in the pleural fluid, were found for patients with rheumatoid pleurisy, malignant effusions, and empyema. In patients with non-malignant inflammatory pleural effusions the concentration of ferritin in pleural fluid correlated significantly with other pleural fluid indices of inflammation: there was a positive correlation with lactate dehydrogenase activity and a negative correlation with concentrations of glucose and complement components C3 and C4. Ferritin was detected immunocytochemically only in the macrophages found among the pleural fluid cells. Our study shows that large amounts of ferritin accumulate locally in the pleural cavity in certain types of pleural inflammation. The accumulation is probably partly the result of increased local reticuloendothelial system activity. Determination of the concentration of ferritin in pleural fluid may provide corroborative information for differential diagnosis and may further our understanding of the pathogenetic events that lead to the perpetuation of inflammatory activity in pleural effusions.
对108例胸腔积液患者的胸腔积液进行了铁蛋白浓度测定。在所有患者组中，胸腔积液中铁蛋白浓度均高于血清。类风湿性胸膜炎、恶性胸腔积液和脓胸患者的差异最大，胸腔积液中铁蛋白含量比血清中高出多达100倍。在非恶性炎症性胸腔积液患者中，胸腔积液中铁蛋白浓度与其他胸腔积液炎症指标显著相关：与乳酸脱氢酶活性呈正相关，与葡萄糖浓度以及补体成分C3和C4呈负相关。仅在胸腔积液细胞中的巨噬细胞中通过免疫细胞化学检测到铁蛋白。我们的研究表明，在某些类型的胸膜炎症中，大量铁蛋白在胸腔局部积聚。这种积聚可能部分是局部网状内皮系统活性增加的结果。测定胸腔积液中铁蛋白浓度可为鉴别诊断提供佐证信息，并可能加深我们对导致胸腔积液炎症活动持续存在的发病机制的理解。
