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慕尼黑肌少症登记处(MUSAR):为提高认知度、增加诊断频率和创新新疗法铺平道路。

The MUnich SArcopenia Registry (MUSAR) : Paving the way for increased visibility, more frequent diagnoses and innovative new treatment.

作者信息

Tausendfreund Olivia, Ferrari Uta, Held Christopher, Martini Sebastian, Mueller Katharina, Reif Hannah, Rippl Michaela, Schluessel Sabine, Schmidmaier Ralf, Drey Michael

机构信息

Department of Medicine IV, LMU University Hospital, LMU Munich, 80336, Munich, Germany.

出版信息

Z Gerontol Geriatr. 2025 May;58(3):197-202. doi: 10.1007/s00391-025-02428-2. Epub 2025 Apr 8.

Abstract

BACKGROUND

The consensus definition of sarcopenia enables a clear diagnostic algorithm. The syndrome can now also be coded in Germany (International Classification of Diseases 10, ICD-10 GM 62.50). Compared to the estimated prevalence it is still significantly underdiagnosed. Current treatment options include resistance training and a protein-rich diet, while pharmacological options are still missing.

OBJECTIVE

The Munich Sarcopenia Registry (MUSAR) aims to raise awareness of the syndrome and affected individuals. Additionally, it seeks to gain insights into risk factors, causes and treatment approaches. This publication conducts an initial analysis of 90 patient datasets with varying degrees of sarcopenia and examines the cohort for key geriatric parameters.

MATERIAL AND METHODS

Since 2018 patients from the geriatric clinic of the Ludwig Maximilians University Munich have been able to contribute their data to the registry. Sociodemographic, anthropometric, functional, and laboratory data are collected in a web-based registry.

RESULTS

Compared to patients without sarcopenia, patients with sarcopenia are significantly older, have more comorbidities and show poorer functional performance as well as reduced quality of life.

DISCUSSION

The results highlight the urgent need for further research and the development of new forms of treatment to improve the quality of life and independence of these patients. Challenges such as difficult recruitment complicate this endeavor. The MUSAR aims to minimize these issues and provides a valuable basis for generating extensive data through the systematic collection of patient data during hospital stays.

摘要

背景

肌肉减少症的共识定义有助于形成清晰的诊断算法。目前,该综合征在德国也可进行编码(国际疾病分类第10版,ICD - 10 GM 62.50)。与估计的患病率相比,其诊断率仍然明显偏低。目前的治疗选择包括阻力训练和富含蛋白质的饮食,而药物治疗选择仍然缺乏。

目的

慕尼黑肌肉减少症登记处(MUSAR)旨在提高对该综合征及受影响个体的认识。此外,它还试图深入了解风险因素、病因和治疗方法。本出版物对90例不同程度肌肉减少症患者的数据集进行了初步分析,并检查了该队列的关键老年医学参数。

材料与方法

自2018年以来,慕尼黑路德维希 - 马克西米利安大学老年病诊所的患者能够将他们的数据贡献给该登记处。社会人口统计学、人体测量学、功能和实验室数据通过基于网络的登记处收集。

结果

与无肌肉减少症的患者相比,有肌肉减少症的患者年龄明显更大,合并症更多,功能表现更差,生活质量更低。

讨论

结果突出表明迫切需要进一步研究并开发新的治疗形式,以提高这些患者的生活质量和独立性。诸如招募困难等挑战使这项工作变得复杂。MUSAR旨在尽量减少这些问题,并通过在住院期间系统收集患者数据为生成大量数据提供有价值的基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e17/12048408/1476ee5ed929/391_2025_2428_Fig1_HTML.jpg

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