Hasegawa Momoka, Katayama Akihiro, Morimoto Eisaku, Watanabe Mayu, Matsushita Yuichi, Takeda Masaya, Hida Kazuyuki
Department of Diabetology and Endocrinology, NHO Okayama Medical Center, Okayama, Japan.
J Diabetes Investig. 2025 Jul;16(7):1346-1349. doi: 10.1111/jdi.70040. Epub 2025 Apr 8.
This case report described a 78-year-old woman with type 1 diabetes who experienced a significant decrease in the hemoglobin glycation index (HGI) after switching her insulin pump from MiniMed™770G to 780G. Despite minimal changes in glycemic control, including a slight decrease in the average sensor glucose and % coefficient of variation (%CV) from continuous glucose monitoring metrics, her glycated hemoglobin level decreased from 8.2% to 7.3%, and HGI decreased from approximately 1.3-0.5. Previous reports have shown that HGI indicates differences in the glycation rate of hemoglobin between individuals. Moreover, a high HGI is a risk factor for diabetic complications. However, there are no reports on changes in HGI within an individual. Therefore, the significance of intraindividual HGI changes, as in this case, should be investigated.
本病例报告描述了一名78岁的1型糖尿病女性，在将胰岛素泵从美敦力™770G更换为780G后，血红蛋白糖化指数（HGI）显著下降。尽管血糖控制变化极小，包括连续葡萄糖监测指标中的平均传感器葡萄糖略有下降和变异系数百分比（%CV）略有下降，但她的糖化血红蛋白水平从8.2%降至7.3%，HGI从约1.3降至0.5。先前的报告表明，HGI表明个体之间血红蛋白糖化率的差异。此外，高HGI是糖尿病并发症的一个危险因素。然而，尚无关于个体内HGI变化的报告。因此，应研究如本病例中个体内HGI变化的意义。
