Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Pennington Biomedical Research Center, Baton Rouge, LA, USA.
J Diabetes Complications. 2022 Jul;36(7):108223. doi: 10.1016/j.jdiacomp.2022.108223. Epub 2022 Jun 2.
A high hemoglobin glycation index (HGI) has been repeatedly associated with greater risk for hypoglycemia in people with diabetes and greater risk for chronic vascular disease in people with or without diabetes. This review explores how different sources of analytical and biological variation in HbA1c and blood glucose individually and collectively affect the clinical information value of HGI. We conclude that HGI is a complex quantitative trait that is a clinically practical biomarker of risk for both hypoglycemia and chronic vascular disease.
高血红蛋白糖基化指数（HGI）已被反复关联到糖尿病患者低血糖风险增加，以及糖尿病患者和非糖尿病患者慢性血管疾病风险增加。本综述探讨了 HbA1c 和血糖的分析和生物学变异的不同来源如何单独和共同影响 HGI 的临床信息价值。我们得出结论，HGI 是一种复杂的定量特征，是低血糖和慢性血管疾病风险的一种临床实用生物标志物。
