Atkinson Jeffrey, Ozer Nesrin Kartal, Manor Danny, Wallert Maria, Galli Francesco
School of Graduate Biomedical Pharmacology and Drug Development Program, Tufts University, Boston, MA, USA.
Department of Chemistry and Centre for Biotechnology, Brock University, St. Catharines, L2S3A1, Ontario, Canada.
Free Radic Biol Med. 2025 Jul;234:277-282. doi: 10.1016/j.freeradbiomed.2025.04.005. Epub 2025 Apr 6.
The 3rd Vitamin E Satellite Symposium (VESS3) "100 years of vitamin E", held in 2022 during the joint meeting of the Society for Free Radical Research (SFRR)-Europe branch and the Plant Oxygen Group (POG), was an occasion to reunite the scientific community interested in vitamin E and debate on its fundamentals in human nutrition one century after its discovery. This conference initiated a discussion forum dedicated to the revision of the nomenclature of vitamin E that was hosted in this journal (https://www.sciencedirect.com/special-issue/10GWS76VWXX). The forum collected 8 papers, including the opening article "Vitamin E discussion forum - position paper on the revision of the nomenclature of vitamin E"(Azzi, Atkinson et al., 2023), that addressed the nomenclature issue essentially suggesting "to restrict to RRR-α-tocopherol the attribute of vitamin E″ and to identify "… other related molecules, including chroman-6-ols (i.e. non-α-tocopherols and tocotrienols) and chromen-6-ols by their chemical names until a disease is identified that is prevented by the specific compounds.". The articles published in this forum issue are summarized and their final considerations critically evaluated. The consensus to have come out of these articles favors the original revision proposal, with the modification of including all 2R stereoisomers of α-tocopherol (α-TOH), in addition to RRR-α-TOH (natural form), in the definition of vitamin E. Further and more rigorous studies on the molecular and clinical aspects of vitamin E essentiality were also advised together with studies on the essentiality of other vitamin E-related compounds.
第三届维生素E卫星研讨会（VESS3）“维生素E的百年历程”于2022年在欧洲自由基研究学会（SFRR）分会和植物氧研究组（POG）的联合会议期间举行，此次会议让对维生素E感兴趣的科学界人士得以重聚，并在维生素E发现一个世纪后，就其在人类营养中的基本原理展开讨论。本次会议发起了一个专门讨论维生素E命名法修订的论坛，该论坛刊载于本期刊（https://www.sciencedirect.com/special-issue/10GWS76VWXX）。该论坛共收集了8篇论文，其中包括开篇文章《维生素E讨论论坛——关于维生素E命名法修订的立场文件》（阿齐、阿特金森等人，2023年），该文章探讨了命名法问题，主要建议“将维生素E的属性限定为RRR-α-生育酚”，并指出“……其他相关分子，包括色满-6-醇（即非α-生育酚和生育三烯酚）和色烯-6-醇，在确定某种特定化合物可预防的疾病之前，用其化学名称来指代”。本论坛特刊发表的文章进行了总结，并对其最终观点进行了批判性评估。这些文章达成的共识支持最初的修订提案，即在维生素E的定义中，除了RRR-α-生育酚（天然形式）之外，还纳入α-生育酚（α-TOH）的所有2R立体异构体。此外，还建议对维生素E必需性的分子和临床方面进行更深入、更严谨的研究，以及对其他与维生素E相关化合物的必需性开展研究。
