Meseeha Marcelle, Dudhat Sanyukta, Sehrish Laraib, Attia Maximos
Hematology/Oncology, Guthrie Medical Group PC, Sayre, Pennsylvania, USA.
Family Medicine, Guthrie Medical Group PC, Sayre, Pennsylvania, USA.
BMJ Case Rep. 2025 Apr 8;18(4):e264826. doi: 10.1136/bcr-2025-264826.
A woman in her 70s, who previously declined colon cancer screening, was diagnosed with colon adenocarcinoma after she presented with melena and anaemia. After she underwent right hemicolectomy and chemotherapy for stage IIIc colon cancer, approximately 1 year later, she was found to have hepatic metastasis and a gastro-oesophageal mass confirmed as gastro-oesophageal adenocarcinoma. This case report sheds light on the challenge that patients and clinicians face in cases of metachronous cancers developing in colorectal cancer survivors, and it raises the consideration for possible improvement of the screening guidelines to help detect metachronous cancers earlier in high-risk patients, hence potentially improving the long-term outcomes for these patients.
一名70多岁的女性，此前拒绝接受结肠癌筛查，在出现黑便和贫血后被诊断为结肠腺癌。她接受了右半结肠切除术并接受了IIIc期结肠癌化疗，大约1年后，发现有肝转移，且一个胃食管肿物经确诊为胃食管腺癌。本病例报告揭示了结直肠癌幸存者发生异时性癌症时患者和临床医生所面临的挑战，并引发了对可能改进筛查指南的思考，以帮助在高危患者中更早地检测出异时性癌症，从而有可能改善这些患者的长期预后。
