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测量胰岛素的力学性质:克服实时、即时护理胰岛素传感挑战的潜在解决方案。

Measuring the Mechanical Properties of Insulin: A Potential Solution to Overcoming the Challenges of Real-Time, Point-of-Care Insulin Sensing.

作者信息

Young Emily, Gutschmidt Stefanie, Chase J Geoffrey

机构信息

Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand.

出版信息

J Diabetes Sci Technol. 2025 Apr 9:19322968251331072. doi: 10.1177/19322968251331072.

DOI:10.1177/19322968251331072
PMID:40200746
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11982062/
Abstract

It is well established real-time, point-of-care capabilities for insulin sensing would provide valuable insight to enhance diabetes management and care in the human body. However, such suitable technology has not yet been developed or commercialized. While not comprehensive, this commentary provides a concise summary of the motivation and challenges of developing real-time, point-of-care insulin sensing technology and offers some comments on current approaches. This short research analysis presents a new perspective on the problem and introduces a future potential solution via measuring the mechanical properties of insulin and discusses the challenges foreseen in the feasibility of this proposed solution.

摘要

实时、即时护理的胰岛素传感功能已得到充分证实,可为改善人体糖尿病管理与护理提供宝贵见解。然而,此类适用技术尚未得到开发或商业化。本评论虽不全面,但简要总结了开发实时、即时护理胰岛素传感技术的动机与挑战,并对当前方法提出了一些看法。这项简短的研究分析从新角度审视了该问题,通过测量胰岛素的机械性能介绍了一种未来可能的解决方案,并讨论了该方案可行性中可预见的挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2f5/11982062/9761c24a3f64/10.1177_19322968251331072-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2f5/11982062/291ff1f8b8db/10.1177_19322968251331072-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2f5/11982062/9761c24a3f64/10.1177_19322968251331072-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2f5/11982062/291ff1f8b8db/10.1177_19322968251331072-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2f5/11982062/9761c24a3f64/10.1177_19322968251331072-fig2.jpg

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本文引用的文献

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Wearable Insulin Biosensors for Diabetes Management: Advances and Challenges.可穿戴胰岛素生物传感器在糖尿病管理中的应用:进展与挑战。
Biosensors (Basel). 2023 Jul 7;13(7):719. doi: 10.3390/bios13070719.
2
Insulin detection in diabetes mellitus: challenges and new prospects.糖尿病中的胰岛素检测:挑战与新展望。
Nat Rev Endocrinol. 2023 Aug;19(8):487-495. doi: 10.1038/s41574-023-00842-3. Epub 2023 May 22.
3
Electrochemical sensor based on molecularly imprinted polymer cryogel and multiwalled carbon nanotubes for direct insulin detection.
基于分子印迹聚合物冷冻凝胶和多壁碳纳米管的电化学传感器用于直接检测胰岛素。
Talanta. 2023 Mar 1;254:124137. doi: 10.1016/j.talanta.2022.124137. Epub 2022 Nov 26.
4
Automated Microfluidic System with Active Mixing Enables Rapid Analysis of Biomarkers in 5 μL of Whole Blood.自动化微流控系统与主动混合技术可实现 5 μL 全血中生物标志物的快速分析。
Anal Chem. 2022 Jul 12;94(27):9706-9714. doi: 10.1021/acs.analchem.2c01139. Epub 2022 May 23.
5
Clinical Evaluation of a Novel Insulin Immunosensor.新型胰岛素免疫传感器的临床评估。
J Diabetes Sci Technol. 2023 Jul;17(4):1038-1048. doi: 10.1177/19322968221074406. Epub 2022 Feb 4.
6
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J Diabetes Sci Technol. 2023 Jul;17(4):1029-1037. doi: 10.1177/19322968211071132. Epub 2022 Jan 19.
7
Development of a POCT type insulin sensor employing anti-insulin single chain variable fragment based on faradaic electrochemical impedance spectroscopy under single frequency measurement.基于单频测量的电化学阻抗Faradaic 检测的抗胰岛素单链可变片段 POCT 型胰岛素传感器的研制。
Biosens Bioelectron. 2022 Mar 15;200:113901. doi: 10.1016/j.bios.2021.113901. Epub 2021 Dec 21.
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Micromachines (Basel). 2021 Feb 11;12(2):178. doi: 10.3390/mi12020178.
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