Carzoli Adrián, Meikle Ana, Pessina Paula
Unidad de Imagenología, Laboratorio de Análisis Clínicos y LEMA, Facultad de Veterinaria-UdelaR, Montevideo, Uruguay.
Open Vet J. 2025 Feb;15(2):619-629. doi: 10.5455/OVJ.2025.v15.i2.10. Epub 2025 Feb 28.
Canine obesity is an increasingly concerning issue that negatively impacts dogs' health, quality of life, and lifespan.
This study aimed to evaluate the adipokine profiles of overweight (OW) and obese (OB) dogs and their associations with various hematological, biochemical, hormonal, and cardiovascular markers.
A total of 84 dogs were classified according to their body condition scores as normal weight (NW), OW, or OB, and were subsequently subjected to blood pressure measurement, blood testing, and urine sampling.
The findings revealed that OB dogs had higher serum concentrations of leptin and resistin while exhibiting lower levels of adiponectin when compared to NW dogs. Additionally, they showed higher systolic blood pressure. Serum creatinine levels were lower in OB dogs, and urinary specific gravity was reduced in both OW and OB dogs compared to their NW counterparts. Furthermore, total leukocyte counts and neutrophil counts were elevated in OW and OB dogs. The study also found that serum insulin levels were positively correlated with triglycerides, cholesterol, and C-reactive protein.
Canine obesity is reflected in altered adipokine concentrations and is associated with insulin resistance, as well as changes in renal function, protein metabolism, and hematological markers.
犬类肥胖是一个日益受到关注的问题，对犬的健康、生活质量和寿命产生负面影响。
本研究旨在评估超重（OW）和肥胖（OB）犬的脂肪因子谱及其与各种血液学、生化、激素和心血管标志物的关联。
根据身体状况评分将84只犬分为正常体重（NW）、OW或OB组，随后进行血压测量、血液检测和尿液采样。
研究结果显示，与NW犬相比，OB犬血清瘦素和抵抗素浓度较高，而脂联素水平较低。此外，它们的收缩压较高。OB犬的血清肌酐水平较低，与NW犬相比，OW和OB犬的尿比重均降低。此外，OW和OB犬的总白细胞计数和中性粒细胞计数升高。研究还发现，血清胰岛素水平与甘油三酯、胆固醇和C反应蛋白呈正相关。
犬类肥胖表现为脂肪因子浓度改变，与胰岛素抵抗以及肾功能、蛋白质代谢和血液学标志物的变化有关。
