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肺癌:肺癌动物模型、肺癌的分子致癌作用以及(某种物质)对肺癌的抗肿瘤作用。 (这里原文“against lung cancer”前缺少关键信息,推测可能是某种物质或治疗手段等,翻译只能按现有内容尽量准确呈现)

Lung cancer: Animal model of lung cancer, molecular carcinogenesis of lung cancer, and antitumor effect of against lung cancer.

作者信息

Kustiati Ulayatul, Nugrahaningsih Dwi Aris Agung, Kusindarta Dwi Liliek, Wihadmadyatami Hevi

机构信息

Post-Graduate School of Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Laboratory of Pharmacology, Faculty of Veterinary Medicine, Universitas Brawijaya, Malang, Indonesia.

出版信息

Open Vet J. 2025 Feb;15(2):482-503. doi: 10.5455/OVJ.2025.v15.i2.1. Epub 2025 Feb 28.

Abstract

Lung cancer is the leading cause of fatalities related to cancer globally. There are numerous ways to treat lung cancer, including surgery, chemotherapy, and radiation. Since these treatments have not yet shown satisfactory results, more research into the underlying mechanisms and different approaches to therapy and prevention are needed. Animal models are essential to the study of lung cancer because they offer priceless information about the etiology, course, and possible treatments for the illness. The therapeutic application of phytochemicals and medicinal plants to treat cancer-related compounds has gained attention subsequently. In addition to discussing the molecular carcinogenic and antitumor effects of the herbal treatment (OS) in connection to lung cancer, this review will address the current awareness regarding lung cancer in animal models. The multitude of animal models used in lung cancer research-such as genetically modified mice, carcinogen-induced models, and xenograft induction-provides a solid foundation for understanding the illness. By easing the examination of the environmental and genetic factors involved and enhancing the analysis of possibilities for treatment, these models eventually assist in the further development of lung cancer therapy. Additionally, using the herb plant OS is essential for both treating and preventing lung cancer. Standardizing dosages and enforcing laws on the use of herbal medications require more in-depth investigation.

摘要

肺癌是全球与癌症相关的主要死亡原因。治疗肺癌有多种方法,包括手术、化疗和放疗。由于这些治疗方法尚未显示出令人满意的效果,因此需要对其潜在机制以及不同的治疗和预防方法进行更多研究。动物模型对于肺癌研究至关重要,因为它们能提供有关该疾病病因、病程及可能治疗方法的宝贵信息。植物化学物质和药用植物在治疗癌症相关化合物方面的治疗应用随后受到了关注。除了讨论草药治疗(OS)与肺癌相关的分子致癌和抗肿瘤作用外,本综述还将阐述目前在动物模型中对肺癌的认识。肺癌研究中使用的多种动物模型,如基因改造小鼠、致癌物诱导模型和异种移植诱导模型,为理解该疾病提供了坚实基础。通过简化对相关环境和遗传因素的研究,并加强对治疗可能性的分析,这些模型最终有助于肺癌治疗的进一步发展。此外,使用草药植物OS对于治疗和预防肺癌都至关重要。标准化剂量以及加强对草药使用的监管需要更深入的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91f9/11974298/76017ee26756/OpenVetJ-15-482-g001.jpg

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