Pierpont G L, DeMaster E G, Reynolds S, Pederson J, Cohn J N
J Lab Clin Med. 1985 Aug;106(2):205-10.
We report myocardial catecholamine levels in primate ventricles assayed by high-pressure liquid chromatography with electrochemical detection. The norepinephrine content of the left ventricles of 11 monkeys (four rhesus and seven cynomolgus) was 1391 +/- 362 ng/gm (+/-SD) with a definite gradient from base (highest) to apex (lowest concentration). Dopamine and epinephrine were present in much lower concentrations (51.8 +/- 24.5 ng/gm and 59.2 +/- 20.0 ng/gm, respectively), but were similarly distributed throughout the left ventricle. There was considerable variation in norepinephrine concentration between animals, but the dopamine/norepinephrine ratio was very consistent within a given animal, averaging 3.7% +/- 1.4%. These values are probably indicative of what normal concentrations of catecholamines are likely to be in humans, and provide a basis for interpretation of results obtained in disease studies.
我们报告了通过高压液相色谱-电化学检测法测定的灵长类动物心室肌儿茶酚胺水平。11只猴子（4只恒河猴和7只食蟹猴）左心室的去甲肾上腺素含量为1391±362 ng/g（±标准差），从心底（最高）到心尖（最低浓度）有明确的梯度。多巴胺和肾上腺素的浓度要低得多（分别为51.8±24.5 ng/g和59.2±20.0 ng/g），但在整个左心室内分布相似。动物之间去甲肾上腺素浓度存在相当大的差异，但在给定动物中多巴胺/去甲肾上腺素比值非常一致，平均为3.7%±1.4%。这些值可能表明人类儿茶酚胺的正常浓度可能是多少，并为解释疾病研究中获得的结果提供了基础。
