Wood J H, Poplack D G, Bleyer W A, Ommaya A K
Science. 1977 Feb 4;195(4277):499-501. doi: 10.1126/science.402027.
Meaningful pharmacokinetic investigations require animal systems which approximate the human situation. This report describes a primate model in which silicone catheters are placed into the fourth ventricle and the spinal subarachnoid space and connected to subcutaneous cerebrospinal fluid without tissue damage, prod, enables spinoventricular perfusion, and permits ventricular cerebrospinal fluid sampling over extended periods in unanethetized rhesus monkeys. This animal system may provide intraventricular pressure recordings and pharmacokinetic data similar to that obtained in man.
有意义的药代动力学研究需要近似人类情况的动物系统。本报告描述了一种灵长类动物模型，其中硅胶导管被置入第四脑室和脊髓蛛网膜下腔，并与皮下脑脊液相连，无组织损伤，可实现脊髓脑室灌注，并允许在未麻醉的恒河猴中长时间采集脑室脑脊液样本。这种动物系统可能提供与人类相似的脑室内压力记录和药代动力学数据。
