Coates D M, Sweet C, Quarles J M, Overton H A, Smith H
J Gen Virol. 1985 Jul;66 ( Pt 7):1627-31. doi: 10.1099/0022-1317-66-7-1627.
Previous work has shown that fever in influenza of ferrets occurs following release of endogenous pyrogen from virus-phagocyte interaction in the upper respiratory tract (URT), and suggested that the poor inflammatory response and correspondingly low fever elicited by A/Puerto Rico/8/34 (H1N1), compared with H3N2 reassortant clones of A/Puerto Rico/8/34-A/England/939/69, were related to its H1 and N1 surface antigens. Nasal virus levels, inflammatory and pyrexial responses produced in ferrets by clones 31 (H3N1) and 64b (H1N2) of the same reassortant system suggested a connection between the H1 antigen and low inflammatory response, but results were not conclusive. Unlike A/Puerto Rico/8/34, two recent H1N1 isolates, A/USSR/90/77 and A/Fiji/15899/83, produced a high inflammatory response yet low fever despite large amounts of virus in the URT, suggesting that either no connection exists between the acquisition of the H1 antigen and production of a low inflammatory response, or the H1 antigen of recent isolates, whilst antigenically related to that of A/Puerto Rico/8/34, is biologically different.
先前的研究表明，雪貂感染流感后发热是由于上呼吸道（URT）中病毒与吞噬细胞相互作用释放内源性热原所致，并提示与A/波多黎各/8/34-A/英格兰/939/69的H3N2重配克隆相比，A/波多黎各/8/34（H1N1）引发的炎症反应较差且发热相应较低，这与其H1和N1表面抗原有关。同一重配系统的克隆31（H3N1）和64b（H1N2）在雪貂中产生的鼻病毒水平、炎症和发热反应表明H1抗原与低炎症反应之间存在联系，但结果并不确凿。与A/波多黎各/8/34不同，最近的两种H1N1分离株A/苏联/90/77和A/斐济/15899/83，尽管上呼吸道中有大量病毒，但仍产生高炎症反应但发热较低，这表明要么H1抗原的获得与低炎症反应的产生之间不存在联系，要么最近分离株的H1抗原虽然在抗原性上与A/波多黎各/8/34的H1抗原相关，但在生物学上有所不同。
