Husseini R H, Sweet C, Collie M H, Smith H
J Infect Dis. 1982 Apr;145(4):520-4. doi: 10.1093/infdis/145.4.520.
The effect of suppression of fever on viral levels in nasal washes of ferrets infected with either of two clones (7a, virulent; 64d, attenuated) of the recombinant influenza virus A/Puerto Rico/8/34-A/England/939/69 (H3N2) was studied. The febrile response was reduced by shaving the ferrets or by treating them with sodium salicylate, which had no noticeable effect on the inflammatory response. For both clones, significantly more virus was shed in the nasal washes of ferrets whose febrile response was suppressed, and the viral levels decreased less rapidly than in untreated ferrets or in those in which the treatments were ineffective.
研究了抑制发热对感染重组甲型流感病毒A/波多黎各/8/34-A/英格兰/939/69（H3N2）两个克隆株（7a，强毒株；64d，弱毒株）之一的雪貂鼻腔冲洗液中病毒水平的影响。通过给雪貂剃毛或用阿司匹林治疗来降低发热反应，这对炎症反应没有明显影响。对于两个克隆株，发热反应受到抑制的雪貂鼻腔冲洗液中排出的病毒明显更多，且病毒水平下降速度比未治疗的雪貂或治疗无效的雪貂更慢。
