Takata Kosei, Yugami Masaki, Karata Soichiro, Karasugi Tatsuki, Uehara Yusuke, Masuda Tetsuro, Nakamura Takayuki, Tokunaga Takuya, Hisanaga Satoshi, Sugimoto Kazuki, Yonemitsu Ryuji, Ideo Katsumasa, Fukuma Yuko, Uragami Masaru, Arima Takahiro, Kawakami Jyunki, Maeda Kazuya, Yoshimura Naoto, Matsunaga Hideto, Kai Yuki, Tanimura Shuntaro, Shimada Masaki, Shibata Yuto, Tateyama Makoto, Takata Shu, Goshogawa Hikaru, Yumoto Mizuho, Takashima Yusuke, Inoue Shinichi, Ueno Syotaro, Kubo Ryuta, Tajiri Rui, Tian Xiao, Honma Fuka, Kawamura Yoshihito, Miyamoto Takeshi
Faculty of Life Sciences, Department of Orthopedic Surgery, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Magnesium Research Center & Department of Material Science, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto, 860-85565, Japan.
Sci Rep. 2025 Apr 10;15(1):12210. doi: 10.1038/s41598-025-96853-3.
Operative treatment is an option for fractures when the fracture is unstable or the patient wishes to return early to daily life or social activities. Metal plates such as titanium and stainless steel are often used in fracture surgery, but the metal plate lacks bone-healing activity and is not bioabsorbable, requiring a second surgery to remove it after bone union. Here we show that a magnesium (Mg) plate made from an alloy of yttrium, zinc, and aluminum with magnesium as the main component in a long-period stacking ordered structure promotes bone formation in a rabbit tibia fracture model and is also bioabsorbable. We show that the Mg plate significantly promoted bone and callus formation compared to a titanium plate in the rabbit tibia fracture model. Moreover, the Mg plate was mostly bioabsorbed once bone union was achieved, but rabbits showed no evidence of biotoxic effects, such as weight loss or increased blood magnesium levels. We also demonstrate that treatment with exogenous magnesium significantly enhanced calcium deposition in an in vitro osteoblast culture system. Magnesium is an essential element, and its radiolucency facilitates observation of the fracture site during Mg plate fixation, while its lack of magnetic properties allows its use in patients who require MRI scans. Accordingly, we propose that a use of a Mg plate could be beneficial in treating bone fracture.
当骨折不稳定或患者希望早日恢复日常生活或社交活动时，手术治疗是一种治疗骨折的选择。钛和不锈钢等金属板常用于骨折手术，但金属板缺乏促进骨愈合的活性且不可生物吸收，在骨愈合后需要二次手术取出。在此，我们展示了一种镁（Mg）板，其由钇、锌和铝与镁的合金制成，具有长周期堆垛有序结构，在兔胫骨骨折模型中可促进骨形成，并且也是可生物吸收的。我们表明，在兔胫骨骨折模型中，与钛板相比，Mg板显著促进了骨和骨痂的形成。此外，一旦实现骨愈合，Mg板大多会被生物吸收，但兔子未表现出生物毒性作用的迹象，如体重减轻或血镁水平升高。我们还证明，在体外成骨细胞培养系统中，外源性镁处理显著增强了钙沉积。镁是一种必需元素，其射线可透性便于在Mg板固定期间观察骨折部位，而其无磁性使其可用于需要进行磁共振成像（MRI）扫描的患者。因此，我们提出使用Mg板可能有益于治疗骨折。
