Nakamoto Mariko, Nishita Yukiko, Tange Chikako, Zhang Shu, Shimokata Hiroshi, Sakai Tohru, Otsuka Rei
Department of Public Health and Applied Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima city, Tokushima, 770-8503, Japan.
Department of Epidemiology of Aging, National Center for Geriatrics and Gerontology, Aichi, Japan.
Eur J Nutr. 2025 Apr 9;64(4):151. doi: 10.1007/s00394-025-03664-3.
This study aimed to clarify the associations between isoflavone intake and the volume changes of brain regions, specifically the hippocampus and total grey matter (TGM), over 10 years in Japanese middle-aged and older community dwellers.
Data from the National Institute for Longevity Sciences-Longitudinal Study of Aging of 654 men and 671 women aged 40-85 years at baseline (6th wave survey, 2008-2010) who participated in the follow-up study (9th wave survey, 2018-2022) were analyzed. Total isoflavone intake was estimated based on a 3-day dietary record and categorized into quintile groups. The volumes of the hippocampus and TGM were measured by T1-weighted magnetic resonance imaging and longitudinal FreeSurfer software. Estimated mean brain volume changes by quintile of total isoflavone intake were assessed by a general linear model, with a stratified analysis by age group (< 65/≥65 years).
There were no significant associations between quintile of isoflavone intake and both brain volume changes over 10 years in all participants. On stratification by age group, the multivariable-adjusted difference over time and % change in hippocampal volume were more strongly associated with quintile of total isoflavone intake in those aged ≥ 65 years (difference over time: p for trend = 0.009; % change: p for trend = 0.012). There were no significant longitudinal associations between quintile of total isoflavone intake and TGM volume change in both age groups.
In older Japanese people aged ≥ 65 years, increased intake of total isoflavones might be a new nutritional strategy to prevent hippocampal atrophy.
本研究旨在阐明日本中老年社区居民在10年期间异黄酮摄入量与脑区（特别是海马体和总灰质（TGM））体积变化之间的关联。
分析了国立长寿科学研究所-衰老纵向研究的数据，该研究选取了654名男性和671名女性作为研究对象，他们在基线时（2008 - 2010年第6次波次调查）年龄为40 - 85岁，并参与了随访研究（2018 - 2022年第9次波次调查）。基于3天的饮食记录估算总异黄酮摄入量，并将其分为五分位数组。通过T1加权磁共振成像和纵向FreeSurfer软件测量海马体和TGM的体积。采用一般线性模型评估按总异黄酮摄入量五分位数划分的估计平均脑体积变化，并按年龄组（<65岁/≥65岁）进行分层分析。
在所有参与者中，异黄酮摄入量五分位数与10年期间的脑体积变化之间均无显著关联。按年龄组分层后，≥65岁人群中海马体体积随时间的多变量调整差异和百分比变化与总异黄酮摄入量五分位数的关联更为强烈（随时间的差异：趋势p值 = 0.009；百分比变化：趋势p值 = 0.012）。在两个年龄组中，总异黄酮摄入量五分位数与TGM体积变化之间均无显著的纵向关联。
在年龄≥65岁的日本老年人中，增加总异黄酮摄入量可能是预防海马体萎缩的一种新的营养策略。
