Blatt G J, Eisenman L M
J Neurogenet. 1985 Feb;2(1):51-66. doi: 10.3109/01677068509100143.
In the homozygous staggerer (sg/sg) mutant mouse, most of the Purkinje cells (the primary targets for olivocerebellar climbing fibers) are missing or ectopic. In this study, the organization and cell number of the inferior olivary complex in sg/sg were determined and compared to the inferior olive of the wildtype (+/+) mouse. Our results indicate that there is a marked disorganization and loss of almost 60% of the cells within the inferior olivary complex. This suggests that the inferior olive may be secondarily affected by the staggerer gene due to the defects in its main target cell, the Purkinje cell.
在纯合子蹒跚突变小鼠（sg/sg）中，大多数浦肯野细胞（橄榄小脑攀缘纤维的主要靶细胞）缺失或异位。在本研究中，确定了sg/sg小鼠下橄榄复合体的组织结构和细胞数量，并与野生型（+/+）小鼠的下橄榄进行了比较。我们的结果表明，下橄榄复合体内存在明显的组织紊乱，且近60%的细胞缺失。这表明，由于其主要靶细胞浦肯野细胞的缺陷，下橄榄可能受到蹒跚基因的继发性影响。
